Dynamic Network of Transcription and Pathway Crosstalk to Reveal Molecular Mechanism of MGd-Treated Human Lung Cancer Cells 英文参考文献.docVIP

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Dynamic Network of Transcription and Pathway Crosstalk to Reveal Molecular Mechanism of MGd-Treated Human Lung Cancer Cells 英文参考文献.doc

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Dynamic Network of Transcription and Pathway Crosstalk to Reveal Molecular Mechanism of MGd-Treated Human Lung Cancer Cells 英文参考文献

DynamicNetworkofTranscriptionandPathway CrosstalktoRevealMolecularMechanismofMGd- TreatedHumanLungCancerCells LiyanShao1.,LishanWang1.,ZhiyunWei1,YuyuXiong1,YangWang1,KefuTang1,YangLi1, GuoyinFeng1,QingheXing3*,LinHe1,2,3* 1Bio-XInstitutes,KeyLaboratory fortheGeneticsofDevelopmentalandNeuropsychiatricDisorders(MinistryofEducation),ShanghaiJiaoTongUniversity,Shanghai, China,2InstituteforNutritionalSciences,ShanghaiInstitutesofBiologicalSciences,ChineseAcademyofSciences,Shanghai,China,3InstitutesofBiomedicalSciences, FudanUniversity,Shanghai,China Abstract Recentresearchhasrevealedvariousmolecularmarkersinlungcancer.However,theorganizationalprinciplesunderlying their genetic regulatory networks still await investigation. Here we performed Network Component Analysis (NCA) and PathwayCrosstalkAnalysis(PCA)toconstructaregulatorynetworkinhumanlungcancer(A549)cellswhichweretreated with 50uM motexafin gadolinium (MGd), a metal cation-containing chemotherapeutic drug for 4, 12, and 24 hours. We identifiedasetofkeyTFs,knowntargetgenesfortheseTFs,andsignalingpathwaysinvolvedinregulatorynetworks.Our work showed that putative interactions between these TFs (such as ESR1/Sp1, E2F1/Sp1, c-MYC-ESR, Smad3/c-Myc, and NFKB1/RELA),betweenTFsandtheirtargetgenes(suchasBMP41/Est1,TSC2/Myc,APE1/Sp1/p53,RARA/HOXA1,andSP1/ USF2),andbetweensignalingpathways(suchasPPARsignalingpathwayandAdipocytokinessignalingpathway).These resultswillprovideinsightsintotheregulatorymechanismofMGd-treatedhumanlungcancercells. Citation:ShaoL,WangL,WeiZ,XiongY,WangY,etal.(2012)DynamicNetworkofTranscriptionandPathwayCrosstalktoRevealMolecularMechanismofMGd- TreatedHumanLungCancerCells.PLoSONE7(5):e31984.doi:10.1371/journal.pone.0031984 Editor:YidongBai,UniversityofTexasHealthScienceCenteratSanAntonio,UnitedStatesofAmerica ReceivedSeptember18,2011;AcceptedJanuary16,2012;PublishedMay31,2012 Copyright: ? 2012 Shao et al. This is an open-access article distributed under the terms of the Creative Commons Attributi