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Effect of Composition Interactions on the Dose Response of an N-Isopropylacrylamide Gel Dosimeter 英文参考文献.docVIP

Effect of Composition Interactions on the Dose Response of an N-Isopropylacrylamide Gel Dosimeter 英文参考文献.doc

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Effect of Composition Interactions on the Dose Response of an N-Isopropylacrylamide Gel Dosimeter 英文参考文献

EffectofCompositionInteractionsontheDoseResponse ofanN-IsopropylacrylamideGelDosimeter Yuan-JenChang1,2*,Bor-TsungHsieh3 1DepartmentofManagementInformationSystems,CentralTaiwanUniversityofScienceandTechnology,Taichung,Taiwan,RepublicofChina,2InstituteofBiomedical Engineering and Material Science, Central Taiwan University of Science and Technology, Taichung, Taiwan, Republic of China, 3Department of Medical Imaging and RadiologicalScience,CentralTaiwanUniversityofScienceandTechnology,Taichung,Taiwan,RepublicofChina Abstract Inthisstudy,atwo-levelfullfactorialdesignwasusedtoidentifytheeffectsoftheinteractionsbetweencompositionsinan N-isopropylacrylamide(NIPAM)geldosimeterinvolvingthefollowingvariables:(A)gelatin,(B)NIPAM,(C)thecrosslinkerN, N9-methylene-bis-acrylamide(Bis),and(D)theantioxidanttetrakis(hydroxymethyl)phosphoniumchloride(THPC).Thedose rangewasfrom0Gyto5Gy.Opticalcomputedtomographywasusedtoscanthepolymergeldosimeter.Eachcomponent wassettotwolevelsforallfourvariables,including(A)4%and6%,(B)4%and6%,(C)2%and4%,aswellas(D)5and 15mM.Responsesurfacemethodologyandacentralcompositedesignwereadoptedforthequantitativeinvestigationof therespectiveinteractioneffectsonthedoseresponsecurveofthegel.Theresultsshowedthatthecontributionsofthe interactioneffects,i.e.,AB(6.22%),AC(8.38%),AD(7.74%),BC(9.44%),ABC(18.24%),BCD(12.66%),andABCD(13.4%),were greaterthanthoseofthefourmaineffects,accountingforover76.08%ofthetotalvariability.Theseresultsalsoindicated thattheNIPAMgelrecipewiththehighestsensitivitywasat40%C(massfractionofBis). Citation: ChangY-J, HsiehB-T (2012) Effect ofCompositionInteractionsonthe DoseResponse ofan N-Isopropylacrylamide GelDosimeter. PLoSONE 7(10): e44905.doi:10.1371/journal.pone.0044905 Editor:SalvatoreV.Pizzo,DukeUniversityMedicalCenter,UnitedStatesofAmerica ReceivedApril16,2012;AcceptedAugust9,2012;PublishedOctober12,2012 Copyright: ? 2012 Chang, Hsieh. This is an open-access article distributed under the terms of the Creative Commons Attributi

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