Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis 英文参考文献.docVIP

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Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis 英文参考文献.doc

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Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis 英文参考文献

ExaminationofApoptosisSignalinginPancreaticCancer byComputationalSignalTransductionAnalysis FelixRu¨ckert1*,GihanDawelbait2,ChristofWinter2,ArndtHartmann3,AxelDenz1,OleAmmerpohl4, MichaelSchroeder2,HansKonradSchackert5,BenceSipos6,Gu¨nterKlo¨ppel6,HolgerKalthoff4, Hans-DetlevSaeger1,ChristianPilarsky1.,RobertGru¨tzmann1. 1DepartmentofVisceral,ThoracicandVascularSurgery,UniversityHospitalCarlGustavCarus,TechnicalUniversityDresden,Dresden,Germany,2BioinformaticsGroup, BiotechnologicalCentre,TechnicalUniversityDresden,Dresden,Germany,3DepartmentofPathology,UniversityofErlangen,Erlangen,Germany,4DivisionofMolecular Oncology,ClinicforGeneralSurgeryandThoracicSurgery,Schleswig-HolsteinUniversityHospitals,Kiel,Germany,5DepartmentofSurgicalResearch,UniversityHospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany, 6Division of Molecular Oncology, Institute for Experimental Cancer Research, Schleswig-Holstein UniversityHospitals,Kiel,Germany Abstract Background:Pancreaticductaladenocarcinoma(PDAC)remainsanimportantcauseofcancerdeath.Changesinapoptosis signalinginpancreaticcancerresultinchemotherapyresistanceandaggressivegrowthandmetastasizing.Theaimofthis studywastocharacterizetheapoptosispathwayinpancreaticcancercomputationallybyevaluationofexperimentaldata fromhigh-throughputtechnologiesandpublicdatabases.Therefore,geneexpressionanalysisofmicrodissectedpancreatic tumor tissue was implemented in a model of the apoptosis pathway obtained by computational protein interaction prediction. Methodology/PrincipalFindings:Apoptosispathwayrelatedgeneswereassembledfromelectronicdatabases.Toassess expression of these genes we constructed a virtual subarray from a whole genome analysis from microdissected native tumor tissue. To obtain a model of the apoptosis pathway, interactions of members of the apoptosis pathway were analysed using public databases and computational prediction of protein interactions. Gene expression data were implementedintheapoptosispathwaym