Extensive Cochleotopic Mapping of Human Auditory Cortical Fields Obtained with Phase-Encoding fMRI 英文参考文献.docVIP

ExtensiveCochleotopicMappingofHumanAuditory CorticalFieldsObtainedwithPhase-EncodingfMRI EllaStriem-Amit1.,UriHertz1,2.,AmirAmedi1,2,3 * 1Department ofMedicalNeurobiology,TheInstitute forMedicalResearchIsrael-Canada (IMRIC),FacultyofMedicine,TheHebrewUniversityofJerusalem,Jerusalem, Israel,2TheEdmondandLilySafraCenterforBrainSciences(ELSC),TheHebrewUniversityofJerusalem,Jerusalem,Israel,3TheCognitiveScienceProgram,TheHebrew UniversityofJerusalem,Jerusalem,Israel Abstract Theprimarysensorycorticesarecharacterizedbyatopographicalmappingofbasicsensoryfeatureswhichisconsideredto deteriorate in higher-order areas in favor of complex sensory features. Recently, however, retinotopic maps were also discoveredinthehigher-ordervisual,parietalandprefrontalcortices.Thediscoveryofthesemapsenabledthedistinction betweenvisualregions,clarifiedtheirfunctionandhierarchicalprocessing.Couldsuchextensionoftopographicalmapping to high-order processing regions apply to the auditory modality as well? This question has been studied previously in animal models but only sporadically in humans, whose anatomical and functional organization may differ from that of animals(e.g.uniqueverbalfunctionsandHeschl’sgyruscurvature).HereweappliedfMRIspectralanalysistoinvestigatethe cochleotopic organization of the human cerebral cortex. We found multiple mirror-symmetric novel cochleotopic maps covering most of the core and high-order human auditory cortex, including regions considered non-cochleotopic, stretching all the way to the superior temporal sulcus. These maps suggest that topographical mapping persists well beyond the auditory core and belt, and that the mirror-symmetry of topographical preferences may be a fundamental principleacrosssensorymodalities. Citation:Striem-AmitE,HertzU,AmediA(2011)ExtensiveCochleotopicMappingofHumanAuditoryCorticalFieldsObtainedwithPhase-EncodingfMRI.PLoS ONE6(3):e17832.doi:10.1371/journal.pone.0017832 Editor:HansOpdeBeeck,UniversityofLeuven,Belgium ReceivedSept