Fractional Dynamics of Globally Slow Transcription and Its Impact on Deterministic Genetic Oscillation 英文参考文献.docVIP

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Fractional Dynamics of Globally Slow Transcription and Its Impact on Deterministic Genetic Oscillation 英文参考文献.doc

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Fractional Dynamics of Globally Slow Transcription and Its Impact on Deterministic Genetic Oscillation 英文参考文献

FractionalDynamicsofGloballySlowTranscriptionand ItsImpactonDeterministicGeneticOscillation KunWei1,2*,ShilongGao1,SuchuanZhong1,HongMa1* 1CollegeofMathematics,SichuanUniversity,Chengdu,SichuanProvince,People’sRepublicofChina,2CollegeofLifeSciences,SichuanUniversity,Chengdu,Sichuan Province,People’sRepublicofChina Abstract Indynamicalsystemstheory,asystemwhichcanbedescribedbydifferentialequationsiscalledacontinuousdynamical system.Instudiesongeneticoscillation,mostdeterministicmodelsatearlystageareusuallybuiltonordinarydifferential equations(ODE).Therefore,genetranscriptionwhichisavitalpartingeneticoscillationispresupposedtobeacontinuous dynamical system by default. However, recent studies argued that discontinuous transcription might be more common than continuous transcription. In this paper, by appending the inserted silent interval lying between two neighboring transcriptionaleventstotheendoftheprecedingevent,weestablishedthattherunningtimeforanintacttranscriptional eventincreasesandgenetranscriptionthusshowsslowdynamics.Bygloballyreplacingtheoriginaltimeincrementforeach state increment by a larger one, we introduced fractional differential equations (FDE) to describe such globally slow transcription.Theimpactoffractionizationongeneticoscillationwasthenstudiedintwoearlystagemodels–theGoodwin oscillatorandtheRo¨ssleroscillator.Byconstructinga‘‘dualmemory’’oscillator–thefractionaldelayGoodwinoscillator,we suggested that four general requirements for generating genetic oscillation should be revised to be negative feedback, sufficientnonlinearity,sufficientmemoryandproperbalancingoftimescale.ThenumericalstudyofthefractionalRo¨ssler oscillatorimpliedthatthegloballyslowtranscriptiontendstolowerthechanceofacoupledormorecomplexnonlinear geneticoscillatorysystembehavingchaotically. Citation: Wei K, Gao S, Zhong S, Ma H (2012) Fractional Dynamics of Globally Slow Transcription and Its Impact on Deterministic Genetic Oscillation. PLoS ONE7(6):e38383.doi:10.1371/journal.p