Fragile X Related Protein 1 Clusters with Ribosomes and Messenger RNAs at a Subset of Dendritic Spines in the Mouse Hippocampus 英文参考文献.docVIP

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Fragile X Related Protein 1 Clusters with Ribosomes and Messenger RNAs at a Subset of Dendritic Spines in the Mouse Hippocampus 英文参考文献.doc

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Fragile X Related Protein 1 Clusters with Ribosomes and Messenger RNAs at a Subset of Dendritic Spines in the Mouse Hippocampus 英文参考文献

FragileXRelatedProtein1ClusterswithRibosomesand MessengerRNAsataSubsetofDendriticSpinesinthe MouseHippocampus DeniseCook1,MariadelRayoSanchez-Carbente2,ClaudeLachance3,DanutaRadzioch3 ,Sandra Tremblay4,EdouardW.Khandjian4,LucDesGroseillers2,KeithK.Murai1* 1Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital,Montreal,Quebec,Canada,2De′partementdeBiochimie,Universite′deMontre′al,Montre′al,Que′bec,Canada,3DivisionofExperimentalMedicine,Departmentof Medicine,McGillUniversity,Montreal,Quebec,Canada,4NeurobiologieCellulaire,CentredeRechercheRobertGiffard,Universite′ Laval,Que′bec,Que′bec, Canada Abstract Theformationandstorageofmemoriesinneuronalnetworksreliesonnewproteinsynthesis,whichcanoccurlocallyat synapsesusingtranslationalmachinerypresentindendritesandatspines.Thesenewproteinssupportlong-lastingchanges in synapse strength and size in response to high levels of synaptic activity. To ensure that proteins are made at the appropriatetimeandlocationtoenablethesesynapticchanges,messengerRNA(mRNA)translationistightlycontrolledby dendritic RNA-binding proteins. Fragile X Related Protein 1 (FXR1P) is an RNA-binding protein with high homology to FragileXMentalRetardationProtein(FMRP)andisknowntorepressandactivatemRNAtranslationinnon-neuronalcells. However,unlikeFMRP,verylittleisknownabouttheroleofFXR1Pinthecentralnervoussystem.TounderstandifFXR1Pis positionedtoregulatelocalmRNAtranslationindendritesandatsynapses,weinvestigatedtheexpressionandtargetingof FXR1P in developing hippocampal neurons in vivo and in vitro. We found that FXR1P was highly expressed during hippocampaldevelopmentandco-localizedwithribosomesandmRNAsinthedendriteandatasubsetofspinesinmouse hippocampalneurons.OurdataindicatethatFXR1Pisproperlypositionedtocontrollocalproteinsynthesisinthedendrite andatsynapsesinthecentralnervoussystem. Citation: Cook D, del Rayo Sanchez-Carbente M, La