Full Restoration of Brucella-Infected Dendritic Cell Functionality through Vγ9Vδ2 T Helper Type 1 Crosstalk 英文参考文献.docVIP

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Full Restoration of Brucella-Infected Dendritic Cell Functionality through Vγ9Vδ2 T Helper Type 1 Crosstalk 英文参考文献.doc

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Full Restoration of Brucella-Infected Dendritic Cell Functionality through Vγ9Vδ2 T Helper Type 1 Crosstalk 英文参考文献

FullRestorationofBrucella-InfectedDendriticCell FunctionalitythroughVc9Vd2THelperType1Crosstalk MingNi1,2,3,DelphineMartire1,2,3,EmmanuelScotet4,MarcBonneville4,FrancoiseSanchez1,2,3, VirginieLafont1,2,3 * 1Universite′ Montpellier 1, Centre d’e′tudes d’agents Pathoge`nes et Biotechnologies pour la Sante′ (CPBS) Montpellier, France, 2CNRS, UMR 5236, CPBS, F-34965 Montpellier,France,3Universite′ Montpellier2,CPBS,F-34095Montpellier,France,4InsermUnite′ MixtedeRecherche892,CentredeRechercheenCance′rologieNantes- Angers,InstitutdeRechercheThe′rapeutiqueUniversite′ deNantes,Nantes,France Abstract Vc9Vd2Tcellsplayanimportantroleintheimmuneresponsetoinfectiousagentsbutthemechanismscontributingtothis immune process remain to be better characterized. Following their activation, Vc9Vd2 T cells develop cytotoxic activity againstinfectedcells,secretelargeamountsofcytokinesandinfluencethefunctionofothereffectorsofimmunity,notably cells playing a key role in the initiation of the adaptive immune response such as dendritic cells. Brucella infection dramatically impairs dendritic cell maturation and their capacity to present antigens to T cells. Herein, we investigated whetherVTcellshavetheabilitytorestorethefullfunctionalcapacitiesofBrucella-infecteddendriticcells.Usinganinvitro multicellularinfectionmodel,weshowedthat:1/Brucella-infecteddendriticcellsactivateVc9Vd2Tcellsthroughcontact- dependentmechanisms,2/activatedVc9Vd2TcellsinducefulldifferentiationintoIL-12producingcellsofBrucella-infected dendritic cells with functional antigen presentation activity. Furthermore, phosphoantigen-activated Vc9Vd2 T cells also play a role in triggering the maturation process of dendritic cells already infected for 24h. This suggests that activated Vc9Vd2Tcellscouldbeusedtomodulatetheoutcomeofinfectiousdiseasesbypromotinganadjuvanteffectindendritic cell-basedcellulartherapies. Citation:NiM,MartireD,ScotetE,BonnevilleM,SanchezF,etal.(2012)FullRestorationofBrucella-InfectedDendriticCell