Full Genome Characterisation of Bluetongue Virus Serotype 6 from the Netherlands 2008 and Comparison to Other Field and Vaccine Strains 英文参考文献.docVIP
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Full Genome Characterisation of Bluetongue Virus Serotype 6 from the Netherlands 2008 and Comparison to Other Field and Vaccine Strains 英文参考文献
FullGenomeCharacterisationofBluetongueVirus
Serotype6fromtheNetherlands2008andComparison
toOtherFieldandVaccineStrains
SushilaMaan1,NarenderS.Maan1,PietA.vanRijn2,Rene′ G.P.vanGennip2,AnnaSanders1,IsabelM.
Wright3,CarrieBatten1,BerndHoffmann4,MichaelEschbaumer4,ChrisA.L.Oura1,AbrahamC.
Potgieter3,KyriakiNomikou1,PeterP.C.Mertens1*
1Vector Borne Diseases Programme, Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, United Kingdom, 2Department of Virology, Central Veterinary
Institute of Wageningen UR, AB Lelystad, The Netherlands, 3Virology Division, Onderstepoort Veterinary Institute, Onderstepoort, South Africa, 4Federal Research
InstituteforAnimalHealth,Greifswald-InselRiems,Germany
Abstract
InmidSeptember2008,clinicalsignsofbluetongue(particularlycoronitis)wereobservedincowsonthreedifferentfarms
ineasternNetherlands(Luttenberg,Heeten,andBarchem),twoofwhichhadbeenvaccinatedwithaninactivatedBTV-8
vaccine (during May-June 2008). Bluetongue virus (BTV) infection was also detected on a fourth farm (Oldenzaal) in the
sameareawhiletestingforexport.BTVRNAwassubsequentlyidentifiedbyrealtimeRT-PCRtargetinggenome-segment
(Seg-)10,inbloodsamplesfromeachfarm.TheviruswasisolatedfromtheHeetensample(IAH‘‘dsRNAvirusreference
collection’’[dsRNA-VRC]isolatenumberNET2008/05)andtypedasBTV-6byRT-PCRtargetingSeg-2.Sequencingconfirmed
thevirustype,showinganidenticalSeg-2sequencetothatoftheSouthAfricanBTV-6live-vaccine-strain.Althoughmostof
theothergenomesegmentsalsoshowedveryhighlevelsofidentitytotheBTV-6vaccine(99.7to100%),Seg-10showed
greatestidentity(98.4%)totheBTV-2vaccine(RSAvvv2/02),indicatingthatNET2008/05hadacquiredadifferentSeg-10by
reassortment. Although Seg-7 from NET2008/05 was also most closely related to the BTV-6 vaccine (99.7/100% nt/aa
identity),theSeg-7sequencederivedfromthebloodsampleofthesameanimal(NET2008/06)wasidenticaltothatofthe
NetherlandsBTV-8(NET2006/04andNET2007/01).ThisindicatesthatthebloodcontainedtwodifferentSeg-7sequences,
oneofwhic
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