Functional Promoter -31GC Variant in Survivin Gene Is Associated with Risk and Progression of Renal Cell Cancer in a Chinese Population 英文参考文献.docVIP

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Functional Promoter -31GC Variant in Survivin Gene Is Associated with Risk and Progression of Renal Cell Cancer in a Chinese Population 英文参考文献.doc

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Functional Promoter -31GC Variant in Survivin Gene Is Associated with Risk and Progression of Renal Cell Cancer in a Chinese Population 英文参考文献

FunctionalPromoter-31G.CVariantinSurvivinGeneIs AssociatedwithRiskandProgressionofRenalCell CancerinaChinesePopulation ChaoQin1.,QiangCao1.,PuLi1.,XiaobingJu1,MeilinWang2,JiaweiChen1,YilongWu1,XiaoxinMeng1, JianZhu1,ZhengdongZhang2,QiangLu1*,ChangjunYin1* 1DepartmentofUrology,TheFirstAffiliatedHospitalofNanjingMedicalUniversity,Nanjing,China,2DepartmentofMolecularandGeneticToxicology,SchoolofPublic Health,NanjingMedicalUniversity,Nanjing,China Abstract Background: Survivin is an inhibitor of apoptosis protein and is involved in the occurrence and progression of human malignancies.Recently,afunctionalpolymorphism(231G.C,rs9904341)inthepromoterofsurvivinhasbeenshownto influenceitsexpressionandconfersusceptibilitytodifferenttypesofcancer.Thepresentstudywasaimedtoinvestigate whetherthepolymorphismalsoinfluencessusceptibilityandprogressionofrenalcellcancer(RCC)inaChinesepopulation. Methods:WegenotypedthispolymorphismusingtheTaqManassayinacase-controlstudycomprisedof710RCCpatients and760controls.ThelogisticregressionwasusedtoassessthegeneticassociationwithoccurrenceandprogressionofRCC. Results: Compared with the genotypes containing G allele (GG and GC), we found a statistically significant increased occurrence of RCC associated with the CC genotype [P=0.006, adjusted odds ratio (OR)=1.38, 95% confidence interval (CI)=1.08–1.76].Thepolymorphismwasassociatedwithriskofdevelopingadvancedstage(OR=2.02,95%CI=1.34–3.07) andmoderatelydifferentiated(OR=1.75;95%CI=1.20–2.54)RCC.Furthermore,thepatientscarryingtheCCgenotypehada significantly greater prevalence of high clinical stage disease (Ptrend=0.003). Similar results were also observed when we restrictedtheanalysistoclearcellRCC,amajorhistologicaltypeofRCC. Conclusions:Ourresultssuggestthatthefunctional231G.Cpolymorphisminthepromoterofsurvivinmayinfluencethe susceptibilityandprogressionofRCCintheChinesepopulation.Largepopulation-basedprospectivestudiesarerequiredto validateourfindings. Citation:QinC,CaoQ,LiP,JuX,WangM,etal.(2