FTO Gene Associated Fatness in Relation to Body Fat Distribution and Metabolic Traits throughout a Broad Range of Fatness 英文参考文献.docVIP

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FTO Gene Associated Fatness in Relation to Body Fat Distribution and Metabolic Traits throughout a Broad Range of Fatness 英文参考文献.doc

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FTO Gene Associated Fatness in Relation to Body Fat Distribution and Metabolic Traits throughout a Broad Range of Fatness 英文参考文献

FTOGeneAssociatedFatnessinRelationtoBodyFat DistributionandMetabolicTraitsthroughoutaBroad RangeofFatness SofiaI.I.Kring1,2*,ClausHolst1,EstherZimmermann1,TineJess1,TinaBerentzen1,S?renToubro3, TorbenHansen4,ArneAstrup6,OlufPedersen4,5,ThorkildI.A.S?rensen1 1InstituteofPreventiveMedicine,CopenhagenUniversityHospitals,CentreforHealthandSociety,Copenhagen,Denmark,2CenterforPharmacogenomics,thePanum Institute,UniversityofCopenhagen,Copenhagen,Denmark,3Reduce–ResearchClinicofNutrition,HvidovreUniversityHospital,Hvidovre,Denmark,4StenoDiabetes Center,Copenhagen,Denmark,5FacultyofHealthScience,UniversityofAarhus,Aarhus,Denmark,6InstituteofHumanNutrition,FacultyofLifeSciences,Universityof Copenhagen,Copenhagen,Denmark Abstract Background: A common single nucleotide polymorphism (SNP) of FTO (rs9939609, T/A) is associated with total body fatness.WeinvestigatedtheassociationofthisSNPwithabdominalandperipheralfatnessandobesity-relatedmetabolic traitsinmiddle-agedmenthroughabroadrangeoffatnesspresentalreadyinadolescence. Methodology/Principal Findings: Obese young Danish men (n=753, BMI$31.0 kg/m2) and a randomly selected group (n=879)fromthesamepopulationwereexaminedinthreesurveys(meanage35,46and49years,respectively).Thetraits included anthropometrics, body composition, oral glucose tolerance test, blood lipids, blood pressure, fibrinogen and aspartate aminotransferase. Logistic regression analysis was used to assess the age-adjusted association between the phenotypesandtheoddsratiosfortheFTOrs9939609(TTandTAgenotypeversustheAAgenotype),foranthropometrics andbodycompositionestimatedperunitz-score.BMIwasstronglyassociatedwiththeAAgenotypeinallthreesurveys: OR=1.17, p=1.1*1026, OR=1.20, p=1.7*1027, OR=1.17, p=3.4*1023, respectively. Fat body mass index was also associated with the AA genotype (OR=1.21, p=4.6*1027 and OR=1.21, p=1.0*1023). Increased abdominal fatness was associated with the AA genotype when measured as waist circumference (OR=1.21, p=2.2*1026 and OR=1.19,