GABAA-Mediated Inhibition Modulates Stimulus-Specific Adaptation in the Inferior Colliculus 英文参考文献.docVIP

下载本文档

4
0
约6.65万字
约 14页
2017-05-11 发布于上海
举报
版权申诉

GABAA-Mediated Inhibition Modulates Stimulus-Specific Adaptation in the Inferior Colliculus 英文参考文献.doc

1、本文档共14页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

GABAA-Mediated Inhibition Modulates Stimulus-Specific Adaptation in the Inferior Colliculus 英文参考文献

GABAA-MediatedInhibitionModulatesStimulus-Specific AdaptationintheInferiorColliculus DavidPe′rez-Gonza′lez1,OlgaHerna′ndez1,2,EllenCovey1,3,ManuelS.Malmierca1,2 * 1Auditory Neurophysiology Unit, Institute of Neuroscience of Castilla y Leo′n, University of Salamanca, Salamanca, Spain, 2Faculty of Medicine, Department of Cell BiologyandPathology,UniversityofSalamanca,Salamanca,Spain,3DepartmentofPsychology,UniversityofWashington,Seattle,WashingtonUnitedStatesofAmerica Abstract The ability to detect novel sounds in a complex acoustic context is crucial for survival. Neurons from midbrain through corticallevelsadapttorepetitivestimuli,whilemaintainingresponsivenesstorarestimuli,aphenomenoncalledstimulus- specific adaptation (SSA). The site of origin and mechanism of SSA are currently unknown. We used microiontophoretic application of gabazine to examine the role of GABAA-mediated inhibition in SSA in the inferior colliculus, the midbrain centerforauditoryprocessing.Wefoundthatgabazinesloweddowntheprocessofadaptationtohighprobabilitystimuli butdidnotabolishit,withresponsemagnitudeandlatencystilldependingontheprobabilityofthestimulus.Blocking GABAA receptors increased the firing rate to high and low probability stimuli, but did not completely equalize the responses. Together, these findings suggest that GABAA-mediated inhibition acts as a gain control mechanism that enhancesSSAbymodifyingtheresponsivenessoftheneuron. Citation: Pe′rez-Gonza′lez D, Herna′ndez O, Covey E, Malmierca MS (2012) GABAA-Mediated Inhibition Modulates Stimulus-Specific Adaptation in the Inferior Colliculus.PLoSONE7(3):e34297.doi:10.1371/journal.pone.0034297 Editor:MelissaJ.Coleman,ClaremontColleges,UnitedStatesofAmerica ReceivedDecember2,2011;AcceptedFebruary28,2012;PublishedMarch29,2012 Copyright:?2012Pe′rez-Gonza′lezetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginal