Gaussian Mixture Model of Heart Rate Variability 英文参考文献.docVIP

GaussianMixtureModelofHeartRateVariability TommasoCosta1*,GiuseppeBoccignone2,MarioFerraro3 1DipartimentodiPsicologia,Universita` diTorino,Torino,Italy,2DipartimentodiScienzedell’Informazione,Universita` diMilano,Milano,Italy,3DipartimentodiFisica, Universita` diTorino,Torino,Italy Abstract Heart rate variability (HRV) is an important measure of sympathetic and parasympathetic functions of the autonomic nervoussystemandakeyindicatorofcardiovascularcondition.ThispaperproposesanovelmethodtoinvestigateHRV, namelybymodellingitasalinearcombinationofGaussians.ResultsshowthatthreeGaussiansareenoughtodescribethe stationary statistics of heart variability and to provide a straightforward interpretation of the HRV power spectrum. Comparisonshavebeenmadealsowithsyntheticdatageneratedfromdifferentphysiologicallybasedmodelsshowingthe plausibilityoftheGaussianmixtureparameters. Citation:CostaT,BoccignoneG,FerraroM(2012)GaussianMixtureModelofHeartRateVariability.PLoSONE7(5):e37731.doi:10.1371/journal.pone.0037731 Editor:Je′re′mie Bourdon,Universite′ deNantes,France ReceivedJanuary20,2012;AcceptedApril23,2012;PublishedMay30,2012 Copyright: ? 2012 Costa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Theauthorshavenosupportorfundingtoreport. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:tommaso.costa@unito.it Introduction X h(t)~ d(t{ti): Heartratevariability(HRV),theamountoffluctuationsaround the mean heart rate, is a valuable tool to investigate the sympathetic and parasympathetic functions of the autonomic nervous system, see, for instance [1] and references therein. In addition, heart rate variability isa keyindicator ofan individual cardiovascular conditionand a prognostic index in the course of myocardialinfarction,heartfailure,diabeticneuropathy,e