Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1 英文参考文献.docVIP

下载本文档

6
0
约4.55万字
约 10页
2017-05-11 发布于上海
举报
版权申诉

Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1 英文参考文献.doc

1、本文档共10页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1 英文参考文献

FunctionalGeneticVariantsinDC-SIGNRAreAssociated withMother-to-ChildTransmissionofHIV-1 Genevie`veBoily-Larouche1,2,Anne-LaureIscache1,LynnS.Zijenah3,JeanH.Humphrey4,AndrewJ. Mouland5,BrianJ.Ward6,MichelRoger1,2* 1Laboratoired’Immunoge′ne′tique,CentredeRechercheduCentreHospitalierdel’Universite′deMontre′al(CRCHUM),Montre′al,Canada,2De′partementdeMicrobiologie et Immunologie, Universite′ de Montre′al, Montre′al, Canada, 3Department of Immunology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe, 4DepartmentofInternationalHealth,JohnsHopkinsBloombergSchoolofPublicHealth,Baltimore,Maryland,UnitedStatesofAmerica,5DepartmentofMedicine,The Lady DavisInstitute forMedicalResearchandMcGillAIDSCenter,McGillUniversity,Montreal,Canada, 6ResearchInstitute oftheMcGillUniversityHospitalComplex, Montreal,Canada Abstract Background:Mother-to-childtransmission(MTCT)isthemaincauseofHIV-1infectioninchildrenworldwide.Giventhatthe C-typelectinreceptor,dendriticcell-specificICAM-grabbingnon-integrin-related(DC-SIGNR,alsoknownasCD209Lorliver/ lymphnode–specificICAM-grabbingnon-integrin(L-SIGN)),caninteractwithpathogensincludingHIV-1andisexpressedat thematernal-fetalinterface,wehypothesizedthatitcouldinfluenceMTCTofHIV-1. MethodsandFindings:ToinvestigatethepotentialroleofDC-SIGNRinMTCTofHIV-1,wecarriedoutageneticassociation study of DC-SIGNR in a well-characterized cohort of 197 HIV-infected mothers and their infants recruited in Harare, Zimbabwe. Infants harbouring two copies of DC-SIGNR H1 and/or H3 haplotypes (H1-H1, H1-H3, H3-H3) had a 3.6-fold increased risk ofin utero(IU) (P=0.013) HIV-1infectionanda5.7-fold increased risk ofintrapartum (IP) (P=0.025)HIV-1 infectionafteradjustingforanumberofmaternalfactors.TheimplicatedH1andH3haplotypessharetwosinglenucleotide polymorphisms(SNPs)inpromoterregion(p-198A)andintron2(int2-180A)thatwereassociatedwithincreasedriskofboth IU (P=0.045 and P=0.003, respectively) and IP (P=0.025, for int2-180A) HIV-1 infection. The