Gene Expression Analysis Reveals the Cell Cycle and Kinetochore Genes Participating in Ischemia Reperfusion Injury and Early Development in Kidney 英文参考文献.docVIP

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Gene Expression Analysis Reveals the Cell Cycle and Kinetochore Genes Participating in Ischemia Reperfusion Injury and Early Development in Kidney 英文参考文献.doc

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Gene Expression Analysis Reveals the Cell Cycle and Kinetochore Genes Participating in Ischemia Reperfusion Injury and Early Development in Kidney 英文参考文献

GeneExpressionAnalysisRevealstheCellCycleand KinetochoreGenesParticipatinginIschemiaReperfusion InjuryandEarlyDevelopmentinKidney Tae-MinKim1.,VictoriaRam?′rez2,4.,JonatanBarrera-Chimal3,4,NormaA.Bobadilla3,4,PeterJ.Park1, VishalS.Vaidya2,5 * 1CenterforBiomedicalInformatics,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,2RenalDivision,DepartmentofMedicine,Brighamand Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3Molecular Physiology Unit, Instituto de Investigaciones Biome′dicas, UniversidadNacionalAuto′nomadeMe′xico,MexicoCity,Mexico,4DepartamentodeNefrolog?′ayMetabolismoMineral,InstitutoNacionaldeCienciasMe′dicasyNutricio′n SalvadorZu′biran,MexicoCity,Mexico,5DepartmentofEnvironmentalHealth,HarvardSchoolofPublicHealth,Boston,Massachusetts,UnitedStatesofAmerica Abstract Background: The molecular mechanisms that mediate the ischemia-reperfusion (I/R) injury in kidney are not completely understood.Itisalsolargelyunknownwhethersuchmechanismsoverlapwiththosegoverningtheearlydevelopmentof kidney. Methodology/PrincipalFindings:Weperformedgeneexpressionanalysistoinvestigatethetranscriptomechangesduring regeneration after I/R injury in the rat (0hr, 6hr, 24hr, and 120hr after reperfusion) and early development of mouse kidney(embryonicday16p.c.andpostnatal1and7day).Pathwayanalysisrevealedawidespectrumofmolecularfunctions that may participate in the regeneration and developmental processes of kidney as well as the functional association betweenthem.Whilethegenesassociatedwithcellcycle,immunity,inflammation,andapoptosisweregloballyactivated during the regeneration after I/R injury, the genes encoding various transporters and metabolic enzymes were down- regulated. We also observed that these injury-associated molecular functions largely overlap with those of early kidney development. In particular, the up-regulation of kinases and kinesins with roles in cell division was common during regenerationandearlydevelop