Gene Expression Profiling in a Mouse Model Identifies Fetal Liver- and Placenta-Derived Potential Biomarkers for Down Syndrome Screening 英文参考文献.docVIP

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Gene Expression Profiling in a Mouse Model Identifies Fetal Liver- and Placenta-Derived Potential Biomarkers for Down Syndrome Screening 英文参考文献.doc

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Gene Expression Profiling in a Mouse Model Identifies Fetal Liver- and Placenta-Derived Potential Biomarkers for Down Syndrome Screening 英文参考文献

GeneExpressionProfilinginaMouseModelIdentifies FetalLiver-andPlacenta-DerivedPotentialBiomarkers forDownSyndromeScreening JeroenL.A.Pennings1*.,WendyRodenburg1.,SandraImholz1,MariaP.H.Koster2,ConnyT.M.van Oostrom1,TimoM.Breit3,PeterC.J.I.Schielen2,AnnemiekedeVries1 1LaboratoryforHealthProtectionResearch(GBO),NationalInstituteforPublicHealthandtheEnvironment(RIVM),Bilthoven,TheNetherlands,2LaboratoryforInfectious Diseases and Perinatal Screening (LIS), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, 3MicroArray Department (MAD), UniversityofAmsterdam(UvA),Amsterdam,TheNetherlands Abstract Background: As a first step to identify novel potential biomarkers for prenatal Down Syndrome screening, we analyzed gene expression in embryos of wild type mice and the Down Syndrome model Ts1Cje. Since current Down Syndrome screeningmarkersarederivedfromplacentaandfetalliver,thesetissueswerechosenastarget. Methodology/PrincipalFindings:Placentaandfetalliverat15.5daysgestationwereanalyzedbymicroarrayprofiling.We confirmedincreasedexpressionofgeneslocatedatthetrisomicchromosomalregion.Overall,betweenthetwogenotypes moredifferentiallyexpressedgeneswerefoundinfetalliverthaninplacenta.Furthermore,thefetalliverdataareinline withthehematologicalaberrationsfoundinhumanswithDownSyndromeaswellasTs1Cjemice.Together,wefound25 targetsthatarepredicted(byGeneOntology,UniProt,ortheHumanPlasmaProteomeproject)tobedetectableinhuman serum. Conclusions/Significance: Fetal liver might harbor more promising targets for Down Syndrome screening studies. We expectthesenewtargetswillhelpfocusfurtherexperimentalstudiesonidentifyingandvalidatinghumanmaternalserum biomarkersforDownSyndromescreening. Citation:PenningsJLA,RodenburgW,ImholzS,KosterMPH,vanOostromCTM,etal.(2011)GeneExpressionProfilinginaMouseModelIdentifiesFetalLiver- andPlacenta-DerivedPotentialBiomarkersforDownSyndromeScreening.PLoSONE6(4):e18866.doi:10.1371/journal.pone.0018866 Editor:GiselaNogales-