Genetic Diversity of Arginine Catabolic Mobile Element in Staphylococcus epidermidis 英文参考文献.docVIP
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Genetic Diversity of Arginine Catabolic Mobile Element in Staphylococcus epidermidis 英文参考文献
GeneticDiversityofArginineCatabolicMobileElement
inStaphylococcusepidermidis
MariaMiragaia1,HerminiadeLencastre1,2,FrancoisePerdreau-Remington3,HenryF.Chambers3 ,Julie
Higashi4,PaulM.Sullam4,JessicaLin5,KesterI.Wong5,KatherineA.King5,MichaelOtto6,GeorgeF.
Sensabaugh5,BinhAnDiep3*
1LaboratoryofMolecularGenetics,InstitutodeTecnologiaQu?′micaeBiolo′gica,UniversidadeNovadeLisboa(ITQB/UNL),Oeiras,Portugal,2LaboratoryofMicrobiology,
TheRockefellerUniversity,NewYork,NewYork,UnitedStatesofAmerica,3DivisionofInfectiousDiseases,DepartmentofMedicine,UniversityofCaliforniaSanFrancisco,
SanFrancisco,California,UnitedStatesofAmerica,4VeteransAffairsMedicalCenterandUniversityofCaliforniaSanFrancisco,SanFrancisco,California,UnitedStatesof
America,5DivisionofInfectiousDiseases,SchoolofPublicHealth,UniversityofCalifornia,Berkeley,California,UnitedStatesofAmerica,6LaboratoryofHumanBacterial
Pathogenesis,NationalInstituteofAllergyandInfectiousDiseases,NationalInstituteofHealth,Bethesda,Maryland,UnitedStatesofAmerica
Abstract
Background: The methicillin-resistant Staphylococcus aureus clone USA300 contains a novel mobile genetic element,
argininecatabolicmobileelement(ACME),thatcontributestoitsenhancedcapacitytogrowandsurvivewithinthehost.
AlthoughACMEappearstohavebeentransferredintoUSA300from S.epidermidis,thegeneticdiversity ofACMEinthe
latterspeciesremainspoorlycharacterized.
Methodology/Principal Findings: To assess theprevalence and geneticdiversity of ACME, 127geographically diverse S.
epidermidisisolatesrepresenting86differentmultilocussequencetypes(STs)werecharacterized.ACMEwasfoundin51%
(65/127)ofS.epidermidisisolates.Thevastmajority(57/65)ofACME-containingisolatesbelongedtothepredominantS.
epidermidis clonal complex CC2. ACME was often found in association with different allotypes of staphylococcal
chromosomecassettemec(SCCmec)whichalsoencodestherecombinasefunctionthatfacilitiesmobilizationACMEfrom
theS.epidermidischromosome.Restrictionfragmentlengthpolymorphism,PCRs
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