Genome-Wide and Candidate Gene Association Study of Cigarette Smoking Behaviors 英文参考文献.docVIP

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Genome-Wide and Candidate Gene Association Study of Cigarette Smoking Behaviors 英文参考文献.doc

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Genome-Wide and Candidate Gene Association Study of Cigarette Smoking Behaviors 英文参考文献

Genome-WideandCandidateGeneAssociationStudyof CigaretteSmokingBehaviors NeilCaporaso1.*,FangyiGu2.,NilanjanChatterjee1.,JinSheng-Chih3,KaiYu1,MeredithYeager1,5, ConstanceChen2,KevinJacobs5,6,WilliamWheeler7,MariaTeresaLandi1,ReginaG.Ziegler1,DavidJ. Hunter1,2,5,StephenChanock4,SusanHankinson2,PeterKraft2.,AndrewW.Bergen8. 1DivisionofCancerEpidemiologyandGenetics,NCI,Bethesda,Maryland,UnitedStatesofAmerica,2PrograminMolecularandGeneticEpidemiology,HarvardSchoolof PublicHealth,Boston,Massachusetts,UnitedStatesofAmerica,3JohnsHopkinsBloombergSchoolofPublicHealth,DepartmentofBiostatistics,Baltimore,Maryland, UnitedStatesofAmerica,4ChanningLaboratory,BrighamandWomens’Hospital,Boston,Massachusetts,UnitedStatesofAmerica,5CoreGenotypingFacility,Advanced TechnologyCenter,NationalCancerInstitute,Gaithersburg,Maryland,UnitedStatesofAmerica,6BioInformedLLC,Gaithersburg,Maryland,UnitedStatesofAmerica, 7InformationManagementServices,Inc.,Rockville,Maryland,UnitedStatesofAmerica,8MolecularGeneticsProgram,CenterforHealthSciences,SRIInternational,Menlo Park,California,UnitedStatesofAmerica Abstract Thecontributionofcommongeneticvariationtooneormoreestablishedsmokingbehaviorswasinvestigatedinajoint analysisoftwogenomewideassociationstudies(GWAS)performedaspartoftheCancerGeneticMarkersofSusceptibility (CGEMS)projectin2,329menfromtheProstate,Lung,ColonandOvarian(PLCO)Trial,and2,282womenfromtheNurses’ HealthStudy(NHS).Weanalyzedsevenmeasuresofsmokingbehavior,fourcontinuous(cigarettesperday[CPD],ageat initiationofsmoking,durationofsmoking,andpackyears),andthreebinary(everversusneversmoking,#10versus.10 cigarettes per day [CPDBI], and current versus former smoking). Association testing for each single nucleotide polymorphism (SNP) was conducted by study and adjusted for age, cohabitation/marital status, education, site, and principalcomponentsofpopulationsubstructure.NoneoftheSNPsachievedgenome-widesignificance(p,1027)inany combinedanalysispoolingevidenceforassociationacrossthetwostud