Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women 英文参考文献.docVIP

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Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women 英文参考文献.doc

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Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women 英文参考文献

Genome-WideAssociationIdentifiesaCommon VariantintheReelinGeneThatIncreases theRiskofSchizophreniaOnlyinWomen Sagiv Shifman1*¤,Martina Johannesson1,Michal Bronstein2,Sam X.Chen3,4,David A.Collier5,Nicholas J.Craddock6, Kenneth S.Kendler3,4,Tao Li5,7,8,Michael O’Donovan6,F.Anthony O’Neill9,Michael J.Owen6,Dermot Walsh10, Daniel R.Weinberger11,Cuie Sun3,4,Jonathan Flint1,Ariel Darvasi2 1 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kindgdom, 2 Department of Genetics, The Institute of Life Sciences, The Hebrew UniversityofJerusalem,Jerusalem,Israel,3DepartmentofPsychiatry,VirginiaCommonwealthUniversity,Richmond,Virginia,UnitedStatesofAmerica,4VirginiaInstitute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America, 5 Social, Genetic and Developmental Psychiatry Centre,InstituteofPsychiatry,King’sCollegeLondon,London,UnitedKingdom,6DepartmentofPsychologicalMedicine,SchoolofMedicine,CardiffUniversity, Cardiff, UnitedKingdom,7PsychiatricLaboratoryandDepartmentofPsychiatry,WestChinaHospital,SichuanUniversity,ThePeople’sRepublicofChina,8StateKeyLaboratoryof Biotherapy,WestChinaHospital,SichuanUniversity,ThePeople’sRepublicofChina,9TheDepartmentofPsychiatry,TheQueensUniversity,Belfast,NorthernIreland,10The Health Research Board, Dublin, Ireland, 11 Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of MentalHealth,NationalInstitutesofHealth(NIH),UnitedStatesDepartmentofHealthandHumanServices,Bethesda,Maryland,UnitedStatesofAmerica Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wideassociationscanforschizophreniainanAshkenaziJewishpopulationusingDNApooling.Wefounda female-specific association with rs7341475, a SNP in the fourth intron of the reelin (RELN) gene (p?2.9310à5 in à4 women), with a significant gene-sex effe