Genetic Variation in MDM2 and p14ARF and Susceptibility to Salivary Gland Carcinoma 英文参考文献.docVIP

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Genetic Variation in MDM2 and p14ARF and Susceptibility to Salivary Gland Carcinoma 英文参考文献.doc

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Genetic Variation in MDM2 and p14ARF and Susceptibility to Salivary Gland Carcinoma 英文参考文献

GeneticVariationinMDM2andp14ARFandSusceptibility toSalivaryGlandCarcinoma LeiJin1,2.,LiXu1,XichengSong1,3.,QingyiWei4,ErichM.Sturgis1,4,GuojunLi1,4 * 1DepartmentofHeadandNeckSurgery,TheUniversityofTexasMDAndersonCancerCenter,Houston,Texas,UnitedStatesofAmerica,2DepartmentofStomatology, Jinling Hospital, School of Medicine, Southern Medical University, Nanjing, China, 3Department of Otorhinolaryngology and Head and Neck Surgery, Yuhuangding Hospital of Qingdao University, Yantai, China, 4Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America Abstract Background:Thep14ARF/MDM2/p53pathwayplaysanimportantroleinmodulationofDNAdamageandoxidativestress responses.TheaimofthisstudywastodeterminewhethergeneticvariantsinMDM2andp14ARFareassociatedwithriskof salivaryglandcarcinoma(SGC). Methods:Foursinglenucleotidepolymorphisms(SNPs)inMDM2andp14ARF (MDM2-rs2279744,MDM2-rs937283,p14ARF - rs3731217, and p14ARF-rs3088440) were genotyped in 156 patients with SGC and 511 cancer-free controls. Multivariate logisticregressionanalysiswasperformedtocalculateoddsratios(ORs)and95%confidenceintervals(CIs). Results:MDM2-rs2279744wassignificantlyassociatedwithamoderatelyincreasedriskofSGC(OR,1.5,95%CI,1.1–2.2). There was a trend toward significantly increased SGC risk with increasing number of risk genotypes of the four polymorphisms(Ptrend=0.004).Individualscarrying3–4riskgenotypesinMDM2andp14ARFwereatincreasedSGCrisk(OR, 2.0, 95% CI, 1.1–2.7) compared with individuals carrying 0–2 risk genotypes. Moreover, the combined effect of risk genotypesofMDM2andp14ARFwasmorepronouncedamongyoungsubjects(#45years),femalesubjects,subjectswith race/ethnicityotherthannon-Hispanicwhite,ever-smokers,andever-drinkers. Conclusion:OurresultssupporttheinvolvementofSNPsofMDM2andp14ARF,eitheraloneormorelikelyincombination,in susceptibilitytoSGC.Largerstudiesareneededtovalidateourfindings. Citation:JinL,XuL,SongX,WeiQ,SturgisEM,etal.(2012)Gene