Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV Infection 英文参考文献.docVIP

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Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV Infection 英文参考文献.doc

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Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV Infection 英文参考文献

GeneticVariationoftheHumana-2-Heremans-Schmid Glycoprotein(AHSG)GeneAssociatedwiththeRiskof SARS-CoVInfection XiaohuiZhu1.,YanWang1,5.,HongxingZhang2,6.,XuanLiu1.,TingChen1,RuifuYang3,YulingShi4, WuchunCao3,PingLi1,QingjunMa1,YunZhai2,6,FuchuHe2,6,GangqiaoZhou2,6*,ChengCao1* 1StateKeyLaboratoryofPathogenandBio-Security,BeijingInstituteofBiotechnology,Beijing,China,2StateKeyLaboratoryofProteomics,BeijingProteomeResearch Center,BeijingInstituteofRadiationMedicine,Beijing,China,3StateKeyLaboratoryofPathogenandBio-Security,InstituteofMicrobiologyandEpidemiology,Beijing, China,4GeneralHospitalofGuangzhouCommand,PLA,Guangzhou,China,5GeneralHospitalofBeijingCommand,PLA,Beijing,China,6NationalEngineeringResearch CenterforProteinDrugs,Beijing,China Abstract GeneticbackgroundmayplayanimportantroleintheprocessofSARS-CoVinfectionandSARSdevelopment.Wefound several proteins that could interact with the nucleocapsid protein of the SARS coronavirus (SARS-CoV). a-2-Heremans- Schmid Glycoprotein (AHSG), which is required for macrophage deactivation by endogenous cations, is associated with inflammatoryregulation.CytochromeP450Family3A(CYP4F3A)isanv-oxidasethatinactivatesLeukotrieneB4(LTB4)in humanneutrophilsandtheliver.Weinvestigatedtheassociationbetweenthepolymorphismsofthesetwoinflammation- associated genes and SARS development. The linkage disequilibrium (LD) maps of these two genes were built with HaploviewusingdataonCHB+JPT(version2)fromtheHapMap.AtotaloftentagSNPswereselectedandgenotyped.In the Guangzhou cohort study, after adjusting for age and sex, two AHSG SNPs and one CYP4F3 SNP were found to be associated with SARS susceptibility: rs2248690 (adjusted odds ratio [AOR] 2.42; 95% confidence interval [CI] 1.30-4.51); rs4917(AOR1.84;95%CI1.02-3.34);andrs3794987(AOR2.01;95%CI1.10–3.68).Tofurthervalidatetheassociation,theten tagSNPsweregenotypedintheBeijingcohort.Afteradjustingforageandsex,onlyrs2248690(AOR,1.63;95%CI,1.30– 2.04)wasfoundtobe associatedwithSARS susceptibility