Genetic Diversity and Population Structure of the Secondary Symbiont of Tsetse Flies, Sodalis glossinidius, in Sleeping Sickness Foci in Cameroon 英文参考文献.docVIP

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Genetic Diversity and Population Structure of the Secondary Symbiont of Tsetse Flies, Sodalis glossinidius, in Sleeping Sickness Foci in Cameroon 英文参考文献.doc

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Genetic Diversity and Population Structure of the Secondary Symbiont of Tsetse Flies, Sodalis glossinidius, in Sleeping Sickness Foci in Cameroon 英文参考文献

GeneticDiversityandPopulationStructureofthe SecondarySymbiontofTsetseFlies,Sodalisglossinidius, inSleepingSicknessFociinCameroon OumarouFarikou1,2,SophieThevenon3,FlobertNjiokou2,Franc?ois Allal4,Ge′rardCuny1,AnneGeiger1* 1UMR177,IRD-CIRAD,CIRADTAA-17/G,CampusInternationaldeBaillarguet,Montpellier,France,2FacultyofScience,UniversityofYaounde′ I,Yaounde′, Cameroon, 3CIRAD,UMRTrypanosomes,Montpellier,France,4CIRAD,UPRDiversite′ Ge′ne′tiqueetAme′liorationdesEspe`cesForestie`res,Montpellier,France Abstract Background: Previousstudieshaveshownsubstantial differencesin Sodalisglossinidius andtrypanosome infectionrates betweenGlossinapalpalispalpalispopulationsfromtwoCameroonianfociofhumanAfricantrypanosomiasis(HAT),Bipindi andCampo.Wehypothesizedthatthegeographicalisolationofthetwofocimayhaveinducedindependentevolutionin thetwoareas,resultinginthediversificationofsymbiontgenotypes. Methodology/PrincipalFindings:Totestthishypothesis,weinvestigatedthesymbiontgeneticstructureusingtheallelicsize variation at four specific microsatellite loci. Classical analysis of molecular variance (AMOVA) and differentiation statistics revealedthatmostofthegeneticdiversitywasobservedamongindividualswithinpopulationsandfrequenthaplotypeswere shared between populations. The structure of genetic diversity varied at different geographical scales, with almost no differentiationwithintheCampoHATfocusandalowbutsignificantdifferentiationbetweentheCampoandBipindiHATfoci. Conclusions/Significance: The data provided new information on the genetic diversity of the secondary symbiont populationrevealingmildstructuring.PossibleinteractionsbetweenS.glossinidiussubpopulationsandGlossinaspeciesthat couldfavortsetseflyinfectionsbyagiventrypanosomespeciesshouldbefurtherinvestigated. Citation:FarikouO,ThevenonS,NjiokouF,AllalF,CunyG,etal.(2011)GeneticDiversityandPopulationStructureoftheSecondarySymbiontofTsetseFlies, Sodalisglossinidius,inSleepingSicknessFociinCameroon.PLoSNeglTropDis5(8):