Genetic Control of Canine Leishmaniasis Genome-Wide Association Study and Genomic Selection Analysis 英文参考文献.docVIP

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Genetic Control of Canine Leishmaniasis Genome-Wide Association Study and Genomic Selection Analysis 英文参考文献.doc

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Genetic Control of Canine Leishmaniasis Genome-Wide Association Study and Genomic Selection Analysis 英文参考文献

GeneticControlofCanineLeishmaniasis:Genome-Wide AssociationStudyandGenomicSelectionAnalysis JavierQuilez1,2*,Vero′nicaMart?′nez1,2,JohnA.Woolliams4,ArmandSanchez1,2,3,RicardoPong-Wong4, LornaJ.Kennedy5,RupertJ.Quinnell6,WilliamE.R.Ollier5,XavierRoura7,Llu?′sFerrer7,LauraAltet2,3, OlgaFrancino2,3 1DepartamentdeGene`ticaAnimal,CentredeRecercaenAgrigeno`mica(CRAG),UniversitatAuto`nomadeBarcelona,Barcelona,Spain,2DepartamentdeCie`nciaAnimali delsAliments,FacultatdeVeterina`ria, UniversitatAuto`nomadeBarcelona,Barcelona,Spain,3ServeiVeterinarideGene`ticaMolecular,DepartamentdeCie`nciaAnimali dels Aliments, Facultat de Veterina`ria, Universitat Auto`noma de Barcelona, Barcelona, Spain, 4The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Scotland,UnitedKingdom,5CentreforIntegratedGenomicMedicalResearch(CIGMR),UniversityofManchester,StopfordBuilding,OxfordRoad,Manchester,United Kingdom,6InstituteofIntegrativeandComparativeBiology,UniversityofLeeds,Leeds,UnitedKingdom,7HospitalCl?′nicVeterinari,UniversitatAuto`nomadeBarcelona, Barcelona,Spain Abstract Background:Thecurrentdiseasemodelforleishmaniasissuggeststhatonlyaproportionofinfectedindividualsdevelop clinicaldisease,whileothersareasymptomaticallyinfectedduetoimmunecontrolofinfection.Thefactorsthatdetermine whether individuals progress to clinical disease following Leishmania infection are unclear, although previous studies suggest a role for host genetics. Our hypothesis was that canine leishmaniasis is a complex disease with multiple loci responsiblefortheprogressionofthediseasefromLeishmaniainfection. Methodology/Principal Findings: Genome-wide association and genomic selection approaches were applied to a population-basedcase-controldatasetof219dogsfromasinglebreed(Boxer)genotypedfor,170,000SNPs.Firstly,we aimed to identify individual disease loci; secondly, we quantified the genetic component of the observed phenotypic variance;andthirdly,wetestedwhethergenome-wideSNPdatacouldaccuratelypredic