Genome-Wide Association Analysis of Soluble ICAM-1 Concentration Reveals Novel Associations at the NFKBIK, PNPLA3, RELA, and SH2B3 Loci 英文参考文献.docVIP

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2017-05-11 发布于上海
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Genome-Wide Association Analysis of Soluble ICAM-1 Concentration Reveals Novel Associations at the NFKBIK, PNPLA3, RELA, and SH2B3 Loci 英文参考文献.doc

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Genome-Wide Association Analysis of Soluble ICAM-1 Concentration Reveals Novel Associations at the NFKBIK, PNPLA3, RELA, and SH2B3 Loci 英文参考文献

Genome-WideAssociationAnalysisofSolubleICAM-1 ConcentrationRevealsNovelAssociationsattheNFKBIK, PNPLA3,RELA,andSH2B3Loci GuillaumePare′1,2,3*,PaulMRidker1,2,LyndaRose1,2,MajaBarbalic4,Jose′eDupuis5,6,AbbasDehghan7,8 , JoshuaC.Bis9,EmeliaJ.Benjamin5,10,11,DovShiffman12,AlexanderN.Parker13,DanielI.Chasman1,2 1CenterforCardiovascularDiseasePrevention,BrighamandWomen’sHospital,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,2DonaldW. Reynolds Center for Cardiovascular Research, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3McMaster University,Hamilton,Canada,4HumanGeneticsCenterandInstituteofMolecularMedicine,UniversityofTexasHealthScienceCenteratHouston,Houston,Texas,United StatesofAmerica,5NationalHeart,Lung,andBloodInstitute’sandBostonUniversity’sFraminghamHeartStudy,Framingham,Massachusetts,UnitedStatesofAmerica, 6Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, 7Department of Epidemiology, Erasmus MedicalCenter,Rotterdam,TheNetherlands,8TheNetherlandsConsortiumonHealthyAging(NCHA),Leiden,TheNetherlands,9CardiovascularHealthResearchUnit, DepartmentofMedicine,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica,10SectionofPreventiveMedicineandEpidemiology,Departmentof Medicine,BostonUniversitySchoolofMedicine,Boston,Massachusetts,UnitedStatesofAmerica,11DepartmentofEpidemiology,BostonUniversitySchoolofPublic Health,Boston,Massachusetts,UnitedStatesofAmerica,12Celera,Alameda,California,UnitedStatesofAmerica,13Amgen,Cambridge,Massachusetts,UnitedStatesof America Abstract SolubleICAM-1(sICAM-1)isanendothelium-derivedinflammatorymarkerthathasbeenassociatedwithdiverseconditions suchasmyocardialinfarction,diabetes,stroke,andmalaria.DespiteevidenceforaheritablecomponenttosICAM-1levels, few genetic loci have been identified so far. To comprehensively address this issue, we performed a genome-wide association analysis of