Global Burden of Human Brucellosis A Systematic Review of Disease Frequency 英文参考文献.docVIP

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Global Burden of Human Brucellosis A Systematic Review of Disease Frequency 英文参考文献.doc

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Global Burden of Human Brucellosis A Systematic Review of Disease Frequency 英文参考文献

GlobalBurdenofHumanBrucellosis:ASystematic ReviewofDiseaseFrequency AnnaS.Dean1,2,LisaCrump1,2,HelenaGreter1,2,EstherSchelling1,2,JakobZinsstag1,2 * 1DepartmentofEpidemiologyandPublicHealth,SwissTropicalandPublicHealthInstitute,Basel,Switzerland,2UniversityofBasel,Basel,Switzerland Abstract Background:Thisreportpresentsasystematicreviewofscientificliteraturepublishedbetween1990–2010relatingtothe frequencyofhumanbrucellosis,commissionedbyWHO.Theobjectivesweretoidentifyhighqualitydiseaseincidencedata tocomplementexistingknowledgeoftheglobaldiseaseburdenand,ultimately,tocontributetowardsthecalculationofa Disability-AdjustedLifeYears(DALY)estimateforbrucellosis. Methods/PrincipalFindings:Thirtythreedatabasesweresearched,identifying2,385articlesrelatingtohumanbrucellosis. Basedonstrictscreeningcriteria,60studieswereselectedforqualityassessment,ofwhichonly29wereofsufficientquality fordataanalysis. Datawereonlyavailablefrom 15countriesintheregions ofNorthernAfrica andMiddleEast, Western Europe,CentralandSouthAmerica,Sub-SaharanAfrica,andCentralAsia.Halfofthestudiespresentedincidencedata,sixof whichwerelongitudinalprospectivestudies,andhalfpresentedseroprevalencedatawhichwereconvertedtoincidence rates. Brucellosis incidence varied widely between, and within, countries. Although study biases cannot be ruled out, demographic,occupational,andsocioeconomicfactorslikelyplayarole.Aggregateddataatnationalorregionallevelsdo notcapturethesecomplexitiesofdiseasedynamicsand,consequently,at-riskpopulationsorareasmaybeoverlooked.In manybrucellosis-endemiccountries,healthsystemsareweakandpassively-acquiredofficialdataunderestimatethetrue diseaseburden. Conclusions:Highqualityresearchisessentialforanaccurateassessmentofdiseaseburden,particularlyinEasternEurope, the Asia-Pacific, Central and South America and Africa where data are lacking. Providing formal epidemiological and statistical training to researchers is essential for improving study quality. An integrated approach to dis