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Global Entrainment of Transcriptional Systems to Periodic Inputs 英文参考文献
GlobalEntrainmentofTranscriptionalSystemsto
PeriodicInputs
GiovanniRusso1,MariodiBernardo1,2*,EduardoD.Sontag3*
1DepartmentofSystemsandComputerEngineering,UniversityofNaplesFedericoII,Naples,Italy,2DepartmentofEngineeringMathematics,UniversityofBristol,Bristol,
UnitedKingdom,3DepartmentofMathematics,RutgersUniversity,Piscataway,NewJersey,UnitedStates
Abstract
Thispaperaddressestheproblemofprovidingmathematicalconditionsthatallowonetoensurethatbiologicalnetworks,
suchastranscriptionalsystems,canbegloballyentrainedtoexternalperiodicinputs.Despiteappearingobviousatfirst,this
isbynomeansagenericpropertyofnonlineardynamicalsystems.Throughtheuseofcontractiontheory,apowerfultool
fromdynamicalsystemstheory,itisshownthatcertainsystemsdrivenbyexternalperiodicsignalshavethepropertythat
alltheirsolutionsconvergetoafixedlimitcycle.Generalresultsareproved,andthepropertiesareverifiedinthespecific
casesofmodelsoftranscriptionalsystemsaswellasconstructsofinterestinsyntheticbiology.Aself-containedexposition
ofallneededresultsisgiveninthepaper.
Citation: Russo G, di Bernardo M, Sontag ED (2010) Global Entrainment of Transcriptional Systems to Periodic Inputs. PLoS Comput Biol 6(4): e1000739.
doi:10.1371/journal.pcbi.1000739
Editor:HerbertM.Sauro,UniversityofWashington,UnitedStatesofAmerica
ReceivedJuly6,2009;AcceptedMarch12,2010;PublishedApril15,2010
Copyright: ? 2010 Russo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:GRandMdBacknowledgesupportfromtheEuropeanUnionProject‘EngineeringComplexityinBiologicalSystems(COBIOS)’,VIFrameworkprogram
(Grant no.043379).EDS acknowledges support fromgrants NSF-DMS-0614371, NIH-1R01GM086881, andAFOSR-FA9550-08. Thefundershad noroleinstudy
design,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript.
CompetingInterests:Theauthorshavedeclaredth
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