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Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians 英文参考文献
HeritabilityofCardiovascular
andPersonalityTraitsin6,148Sardinians
Giuseppe Pilia1[z,Wei-Min Chen2[,Angelo Scuteri3,4,Marco Orru′1,5,Giuseppe Albai1,Mariano Dei1,Sandra Lai1,
GianlucaUsala1,MonicaLai1,PaolaLoi1,CinziaMameli1,LoredanaVacca1,ManilaDeiana1,NazarioOlla1,MarcoMasala1,
AntonioCao1,SamerS.Najjar4,AntonioTerracciano4,TimurNedorezov4,AlexeiSharov4,AlanB.Zonderman4,
Gonc?alo R.Abecasis2*,PaulCosta4,EdwardLakatta4,DavidSchlessinger4*
1IstitutodiNeurogeneticaeNeurofarmacologia,ConsiglioNazionaledelleRicerche,OspedaleMicrocitemico,Cagliari,Italy,2CenterforStatisticalGenetics,Departmentof
Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America, 3 Unita` Operativa Geriatria, Istituto Nazionale Riposo e Cura Anziani, Rome, Italy,
4GerontologyResearchCenter,NationalInstituteonAging,Baltimore,Maryland,UnitedStatesofAmerica,5Unita` OperativaSempliceCardiologia,DivisionediMedicina,
PresidioOspedalieroSantaBarbara,Iglesias,Italy
Infamilystudies,phenotypicsimilaritiesbetweenrelativesyieldinformationontheoverallcontributionofgenesto
traitvariation.Largesamplesareimportantforthesefamilystudies,especiallywhencomparingheritabilitybetween
subgroupssuchasyoungandold,ormalesandfemales.Werecruitedacohortof6,148participants,aged14–102y,
from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we
implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze
multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative
traits,focusingonfacetsofpersonalityandcardiovascularfunction.Wealsosummarizeresultsofbivariateanalyses
forallpairsoftraitsandofheterogeneityanalysesforeachtrait.Wefoundasignificantgeneticcomponentforevery
trait. On average, genetic effects explained 40% of the variance for 38 blood tests, 51% for five anthropometric
measures, 25% for 20 measures of cardiovascular functi
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