桦褐孔菌中的活性化合物桦褐孔菌醇.pdfVIP

Pharm Care Res 2009 Dec; 9( 6) , . # 455 # # # 1 2 2 3 * 赵芬琴 , 邓丽颖 ,杨灿宇 ,朴惠善 ( 1. , 475004;2. , 453600; 3. , 133000) [ ] , , , [ ] ; ; ;; [ ] R 979. 19 [] A [ ] 1671-2838( 2009)06-0455-04 Inotodiol- the active compound in I nonotus obliq uus 1 2 2 3* ZHAO Fen-qin , DE G L-i ying , YA G Can-yu , PIAO Hu-i shan ( 1. Institute of atural Products, Henan University, Kaifeng 475004, China; 2. Department of Pharmacy, Peoples Hospital of Huixian of Henan Province, Huixian 453600, China; 3. Department of atural Medicinal Chemistry,School of Pharmacy, Yanbian University, Yanji 133000, China) [ABSTRACT] Literature on inotodiol at home and abroad are analyzed, summarized and comprehensively evaluated in this pa- per. Discovery, chemical structure, pharmacological activities, structural modification, sem-i synthesis and mycelia culture in v itr o are introduced for the purpose of providing referencefor further research on inotodiol. [ KEY WORDS] I nonot us obl iq uus ; inotodiol;chemical constituents;antineoplastic agents; review [Pharm Care Res, 2009,9( 6) : 455-458] ( I nonot us obl iquus Pilat) , , 45b~ 50b ,16 C30H50 O2 ,442, ( ) , 17 , 15 o [2-7] 1821 1~ 18219 e , [A]D + 56 [ 1] 20 50 , :-( Liebermann-Bur- chard ) , ; - ( inotodiol) (Salkowski ) ; , , (Rosenheim ) : , UVK 244 nm( E = 270) 252 nm( E = 215) max , ,