Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells 英文参考文献.docVIP

LactateActivatesHIF-1inOxidativebutNotinWarburg- PhenotypeHumanTumorCells ChristopheJ.DeSaedeleer,TamaraCopetti,PaoloE.Porporato,JulienVerrax,OlivierFeron., PierreSonveaux*. PoleofPharmacology,InstitutdeRecherchesExpe′rimentalesetCliniques(IREC),Universite′ catholiquedeLouvain(UCL),Brussels,Belgium Abstract Cancercanbeenvisionedasametabolicdiseasedrivenbypressureselectionandintercellularcooperativeness.Together with anaerobic glycolysis, the Warburg effect, formally corresponding to uncoupling glycolysis from oxidative phosphorylation, directly participates in cancer aggressiveness, sup