Large-Scale Differential Proteome Analysis in Plasmodium falciparum under Drug Treatment 英文参考文献.docVIP

Large-ScaleDifferentialProteomeAnalysisin PlasmodiumfalciparumunderDrugTreatment JudithHelenaPrieto1.,SasaKoncarevic2.,SungKyuPark1,JohnYates,III1*,KatjaBecker2* 1DepartmentofCellBiology,TheScrippsResearchInstitute,LaJolla,California,UnitedStatesofAmerica, 2InterdisciplinaryResearchCenter,Justus-Liebig-University, Giessen,Germany Abstract Proteomestudiescontributemarkedlytoourunderstandingofparasitebiology,host-parasiteinteractions,andmechanisms of drug action. For most antimalarial drugs neither mode of action nor mechanisms of resistance development are fully elucidatedalthoughthis