Large-Scale Bi-Level Strain Design Approaches and Mixed-Integer Programming Solution Techniques 英文参考文献.docVIP

Large-ScaleBi-LevelStrainDesignApproachesand Mixed-IntegerProgrammingSolutionTechniques JoonhoonKim1,2,JenniferL.Reed1,2*,ChristosT.Maravelias1,2 * 1Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 2DOE Great Lakes Bioenergy ResearchCenter,UniversityofWisconsin-Madison,Madison,Wisconsin,UnitedStatesofAmerica Abstract Theuseofcomputationalmodelsinmetabolicengineeringhasbeenincreasingasmoregenome-scalemetabolicmodels andcomputationalapproachesbecomeavailable.Variouscomputationalapproacheshavebeendevelopedtopredict