原创力文档Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease 英文参考文献.docVIP
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Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease 英文参考文献
Large-ScaleGene-CentricAnalysisIdentifiesNovel
VariantsforCoronaryArteryDisease
TheIBC50KCADConsortium*
Abstract
Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement
genome-wideassociation(GWA)studies,weconductedalargeandsystematiccandidategenestudyofCADsusceptibility,
includinganalysisofmanyuncommonandfunctionalvariants.Weexamined49,094geneticvariantsin,2,100genesof
cardiovascularrelevance,usingacustomisedgenearrayin15,596CADcasesand34,992controls(11,202casesand30,733
controlsofEuropeandescent;4,394 casesand4,259controlsofS
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