钙蛋白酶与阿尔茨海默病关系的研究进展.docVIP

　　钙蛋白酶与阿尔茨海默病关系的研究进展 【关键词】 阿尔茨海默病 tau蛋白质类 淀粉样β蛋白 细胞凋亡 综述( 钙蛋白酶可能通过水解钙调磷酸酶（calcineurin,CaN）使之活化参与凋亡基因的调控。Ray等用H2O2及A23187诱导PC12细胞凋亡时,Bax mRNA的表达无显著变化,而Bc12 mRNA表达水平下降,导致Bax/Bcl2比率增高,而用细胞膜通透性选择性钙蛋白酶抑制剂MDL28170可抑制Bax/Bcl2比率增高,表明钙蛋白酶可能通过提高细胞内Bax/Bcl2表达的比率,促进细胞凋亡[21]。此外，oldoveanu T,Hosfield C M,Lim D,et al. A Ca(2+)san platelets\[J\]. Platelets, 2000,11(4):189198. \[6\]Zalepson V F,Goll D E. Effect of phosphatidylinositol and insideout erythrocyte vesicles on autolysis of mu and mcalpain from bovine skeletal muscle\[J\]. Biochim Biophys Acta, 2004,1693(2):125133. \[7\]Rock M T,Dix A R,Brooks ,et al. Membrane proximal ERK signaling is required for Mcalpain activation do of epidermal gro, 2001,276(26):2334123348. \[9\]Cong J,Thompson V F,Goll D E. Phosphorylation of the calpains\[J\]. Mol Biol Cell, 2000,11:386a. \[10\]Glading A,Chang P,Lauffenburger D A,et al. Epidermal grootility and occurs via an ERK/MAP kinase signaling path, 2000,275(4):23902398. \[11\]Shiraha H,Glading A,Chou J,et al. Activation of mcalpain(calpain Ⅱ) by epidermal groited by protEin kinase A phosphorylation of mcalpain\[J\]. Mol Cell Biol, 2002,22(8):27162727. \[12\]Smith S D,Jia Z,Huynh K K,et al. Glutamate substitutions at a PKA consensus site are consistent dyshomeostasis and intracellular signalling in AlzhEImers disease\[J\]. Nat Rev Neurosci, 2002,3(11):862872. \[14\]Mattson M P,Chan S L. Neuronal and glial calcium signaling in Alzheimers disease\[J\]. Cell Calcium, 2003,34(45):385397. \[15\] Fifre A,Sponne I,Koziel V,et al. Microtubuleassociated protein MAP1A,MAP1B,and MAP2 proteolysis during soluble amyloid betapeptideinduced neuronal apoptosis\[J\]. J Biol Chem, 2006,281(1):229240. \[16\]Fang Z Y,Liu S J,APK pathers disease\[J\]. Am J Pathol, 2004,165(3):795805. \[21\]Ray S K,Fidan M,Noer disease brain\[J\]. J Biol Chem, 2005,280(45):3775537762. \[24\]izaediated cleavage of calcineurin in excitotoxic neurodegeneration\[J\]. J Biol Chem, 2004,