Medulloblastoma Exosome Proteomics Yield Functional Roles for Extracellular Vesicles 英文参考文献.docVIP

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Medulloblastoma Exosome Proteomics Yield Functional Roles for Extracellular Vesicles 英文参考文献.doc

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Medulloblastoma Exosome Proteomics Yield Functional Roles for Extracellular Vesicles 英文参考文献

MedulloblastomaExosomeProteomicsYieldFunctional RolesforExtracellularVesicles LauraM.Epple1,2,SteveG.Griffiths3,AnjelikaM.Dechkovskaia4,NathanielL.Dusto1,JasonWhite1, RodneyJ.Ouellette3,ThomasJ.Anchordoquy5,LynneT.Bemis6,MichaelW.Graner1* 1Department of Neurosurgery, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America, 2Cell and Molecular Biology Program,CancerBiology,CollegeofVeterinaryMedicineandBiomedicalSciences,ColoradoStateUniversity,FortCollins,Colorado,UnitedStatesofAmerica,3Atlantic CancerResearchInstitute,Moncton,NewBrunswick,Canada,4DepartmentofSurgery,DukeUniversityMedicalCenter,Durham,NorthCarolina,UnitedStatesofAmerica, 5SchoolofPharmacy,AnschutzMedicalCenter,UniversityofColoradoDenver,Aurora,Colorado,UnitedStatesofAmerica,6DepartmentofMedicalOncology,Anschutz MedicalCenter,UniversityofColoradoDenver,Aurora,Colorado,UnitedStatesofAmerica Abstract Medulloblastomasarethemostprevalentmalignantpediatricbraintumors.Survivalforthesepatientshasremainedlargely thesameforapproximately20years,andourtherapiesforthesecancerscausesignificanthealth,cognitive,behavioraland developmentalsequelaeforthosewhosurvivethetumorandtheirtreatments.Weobviouslyneedabetterunderstanding ofthebiologyofthesetumors,particularlywithregardtotheirmigratory/invasivebehaviors,theirproliferativepropensity, andtheirabilitiestodeflectimmuneresponses.Exosomes,virus-sizedmembranevesiclesreleasedextracellularlyfromcells afterformationin,andtransitthru,theendosomalpathway,mayplayrolesinmedulloblastomapathogenesisbutareasyet unstudied in this disease. Here we characterized exosomes from a medulloblastoma cell line with biochemical and proteomic analyses, and included characterization of patient serum exosomes. Further scrutiny of the proteomic data suggestedfunctionalpropertiesoftheexosomesthatarerelevanttomedulloblastomatumorbiology,includingtheirroles asproliferationstimulants,theiractivitiesasattractantsfortumorcellmigration,andtheirimmunemodula