Microbleed Detection Using Automated Segmentation (MIDAS) A New Method Applicable to Standard Clinical MR Images 英文参考文献.docVIP

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Microbleed Detection Using Automated Segmentation (MIDAS) A New Method Applicable to Standard Clinical MR Images 英文参考文献.doc

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Microbleed Detection Using Automated Segmentation (MIDAS) A New Method Applicable to Standard Clinical MR Images 英文参考文献

MicrobleedDetectionUsingAutomatedSegmentation (MIDAS):ANewMethodApplicabletoStandardClinical MRImages MohamedL.Seghier1,MagdalenaA.Kolanko2,AlexanderP.Leff3,HansR.Ja¨ger2,SimoneM.Gregoire2, DavidJ.Werring2* 1WellcomeTrustCentreforNeuroimaging,UniversityCollegeLondonInstituteofNeurology,London,UnitedKingdom,2StrokeResearchGroup,DepartmentofBrain RepairandRehabilitation,UniversityCollegeLondonInstituteofNeurology,London,UnitedKingdom,3UniversityCollegeLondonInstituteofCognitiveNeuroscience, London,UnitedKingdom Abstract Background:Cerebralmicrobleeds,visibleongradient-recalledecho(GRE)T2*MRI,havegeneratedincreasinginterestas animagingmarkerofsmallvesseldiseases,withrelevanceforintracerebralbleedingriskorbraindysfunction. Methodology/PrincipalFindings:Manualratingmethodshavelimitedreliabilityandaretime-consuming.Wedevelopeda new method for microbleed detection using automated segmentation (MIDAS) and compared it with a validated visual ratingsystem.Inthirtyconsecutivestrokeservicepatients,standardGRET2*imageswereacquiredandmanuallyratedfor microbleeds by atrained observer. Afterspatially normalizing each patient’s GRE T2* imagesinto a standard stereotaxic space,theautomatedmicrobleeddetectionalgorithm(MIDAS)identifiedcerebralmicrobleedsbyexplicitlyincorporating an‘‘extra’’ tissue class forabnormal voxels within aunified segmentation-normalization model.The agreement between manual and automated methods was assessed using the intraclass correlation coefficient (ICC) and Kappa statistic. We foundthatMIDAShadgenerallymoderatetogoodagreementwiththemanualreferencemethodforthepresenceoflobar microbleeds (Kappa=0.43, improved to 0.65 after manual exclusion of obvious artefacts). Agreement for the number of microbleedswasverygoodforlobarregions:(ICC=0.71,improvedtoICC=0.87).MIDASsuccessfullydetectedallpatients withmultiple($2)lobarmicrobleeds. Conclusions/Significance:MIDAScanidentifymicrobleedsonstandardMRdatasets,andwithanadditionalrapidediting step shows good agreement wi