Modifications of Default-Mode Network Connectivity in Patients with Cerebral Glioma 英文参考文献.docVIP

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Modifications of Default-Mode Network Connectivity in Patients with Cerebral Glioma 英文参考文献.doc

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Modifications of Default-Mode Network Connectivity in Patients with Cerebral Glioma 英文参考文献

ModificationsofDefault-ModeNetworkConnectivityin PatientswithCerebralGlioma RobertoEsposito1,2.,PeterA.Mattei1,2.,ChiaraBriganti1,2,GianLucaRomani1,2,ArmandoTartaro1,2 MassimoCaulo1,2 , * 1Institute for Advanced Biomedical Technologies, ‘‘G. D’Annunzio’’ University Foundation, Chieti, Italy, 2Department of Neuroscience and Imaging, University of ‘‘G. D’Annunzio,’’Chieti,Italy Abstract Purpose:TheaimofthestudywastoevaluateconnectivitymodificationsintheDefaultModeNetwork(DMN)inpatients withcerebralglioma,andtocorrelatethesemodificationstotumorcharacteristics. Methods:Twenty-fourpatientswithaleft-hemispherecerebraltumor(14gradeIIand10gradeIVgliomas)and14healthy age-matchedright-handvolunteerswereenrolledinthestudy.SubjectsunderwentfMRIwhileperforminglanguagetasks for presurgical mapping. Data was analyzed with independent component analysis in order to identify the DMN. DMN groupmapswereproducedbyrandom-effectanalysis(p,0.001,FDR-corrected).Ananalysisofvarianceacrossthethree groups(p,0.05)andpost-hoct-testcontrastsbetweenpairsofgroupswerecalculated(p,0.05,FDR-corrected). Results:AllthreegroupsshowedtypicalDMNareas.However,reducedDMNconnectivitywasdetectedintumorpatients withrespecttocontrols.AsignificantlyincreasedandreducedintegrationofDMNareaswasobservedinthehippocampal andprefrontalregions,respectively.Modificationswerecloselyrelatedtotumorgrading.Moreover,theDMNlateralizedto thehemispherecontralateraltotumorinthelow-grade,butnotinthehigh-gradetumorpatients. Conclusion:ModificationsofDMNconnectivitywereinducedbygliomasanddifferedforhighandlowgradetumors. Citation: EspositoR, Mattei PA, Briganti C, Romani GL,Tartaro A, et al.(2012) Modifications ofDefault-Mode Network Connectivityin Patients with Cerebral Glioma.PLoSONE7(7):e40231.doi:10.1371/journal.pone.0040231 Editor:Yu-FengZang,HangzhouNormalUniversity,China ReceivedJanuary16,2012;AcceptedJune3,2012;PublishedJuly9,2012 Copyright: ? 2012 Esposito et al. This is an open-access article distributed under the terms