Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles 英文参考文献.docVIP

下载本文档

12
0
约2.94万字
约 6页
2017-05-12 发布于上海
举报
版权申诉

Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles 英文参考文献.doc

1、本文档共6页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles 英文参考文献

ModulatingPharmacokinetics,TumorUptakeand BiodistributionbyEngineeredNanoparticles RochelleR.Arvizo1,OscarR.Miranda2,DanielF.Moyano2,ChadA.Walden3,KarunaGiri1 ,Resham Bhattacharya1,J.DavidRobertson5,VincentM.Rotello2,JoelM.Reid3,PriyabrataMukherjee1,4,6* 1DepartmentofBiochemistryandMolecularBiology,MayoClinicRochester,Rochester,Minnesota,UnitedStatesofAmerica,2DepartmentofChemistry,Universityof Massachusetts,Amherst,Massachusetts,UnitedStatesofAmerica,3DepartmentofOncology,MayoClinicRochester,Rochester,Minnesota,UnitedStatesofAmerica, 4Department of Physiology and Biomedical Engineering, Mayo Clinic Rochester, Rochester, Minnesota, United States of America, 5Department of Chemistry and UniversityofMissouriResearchReactor,UniversityofMissouri,Columbia,Missouri,UnitedStatesofAmerica,6MayoClinicCancerCenter,MayoClinicCollegeofMedicine, Rochester,Minnesota,UnitedStatesofAmerica Abstract Background: Inorganic nanoparticles provide promising tools for biomedical applications including detection, diagnosis andtherapy.Whilesurfacepropertiessuchaschargeareexpectedtoplayanimportantroleintheirinvivobehavior,very little is known how the surface chemistry of nanoparticles influences their pharmacokinetics, tumor uptake, and biodistribution. Method/Principal Findings: Using a family of structurally homologous nanoparticles we have investigated how pharmacological properties including tumor uptake and biodistribution are influenced by surface charge using neutral (TEGOH),zwitterionic(Tzwit),negative(TCOOH)andpositive(TTMA)nanoparticles.Nanoparticleswereinjectedintomice (normalandathymic)eitherinthetailveinorintotheperitoneum. Conclusion:NeutralandzwitterionicnanoparticlesdemonstratedlongercirculationtimeviabothIPandIVadministration, whereas negatively and positively charged nanoparticles possessed relatively short half-lives. These pharmacological characteristics were reflected on the tumor uptake and biodistribution of the respective nanoparticles, with enhanced tumoruptakebyn