Modulation of the Disturbed Motor Network in Dystonia by Multisession Suppression of Premotor Cortex 英文参考文献.docVIP

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Modulation of the Disturbed Motor Network in Dystonia by Multisession Suppression of Premotor Cortex 英文参考文献.doc

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Modulation of the Disturbed Motor Network in Dystonia by Multisession Suppression of Premotor Cortex 英文参考文献

ModulationoftheDisturbedMotorNetworkinDystonia byMultisessionSuppressionofPremotorCortex Ying-ZuHuang1,Chin-SongLu1,JohnC.Rothwell2,Chung-ChuanLo3,Wen-LiChuang1,Yi-HsinWeng1, Szu-ChiaLai1,Rou-ShaynChen1* 1DepartmentofNeurology,ChangGungMemorialHospitalandChangGungUniversityCollegeofMedicine,Taipei,Taiwan,2SobellDepartmentofMotorNeuroscience andMovementDisorders,InstituteofNeurology,UniversityCollegeLondon,QueenSquare,London,UnitedKingdom,3InstituteofSystemsNeuroscience,NationalTsing HuaUniversity,Hsinchu,Taiwan Abstract Daily sessions of therapeutic transcranial brain stimulation are thought to prolong or amplify the effect of a single intervention.Hereweshowinpatientswithfocalhanddystoniathatadditional,neweffectsbuildupprogressivelyover time, making it difficult to predict the effect of long term interventions from shorter treatment sessions. In a sham- controlledstudy,realorshamcontinuousthetaburststimulation(cTBS)wasgivenoncedailyforfiveconsecutivedaysto dorsolateral premotor cortex (PMd). Five days of real, but not sham, premotor cTBS improved intracortical inhibition in primarymotorcortex(M1)toasimilarextentonday1andday5.However5daysofcTBSwererequiredtorestorethe abnormalPMd-M1interactionsobservedonday1.Similarly,excessiveM1plasticityseenatbaselinewasalsosignificantly reducedbyfivedaysofrealpremotorcTBS.Therewasonlyamarginalbenefitonwriting.Theresultsshowthatadditional, neweffects,atsitesdistantfromthepointofstimulation,buildupprogressivelyovertime,makingitdifficulttopredictthe effect of long term interventions from shorter treatment sessions. The results indicate that it may take many days of therapeuticinterventiontorebalanceactivityinacomplexnetwork. Citation:HuangY-Z,LuC-S,RothwellJC,LoC-C,ChuangW-L,etal.(2012)ModulationoftheDisturbedMotorNetworkinDystoniabyMultisessionSuppression ofPremotorCortex.PLoSONE7(10):e47574.doi:10.1371/journal.pone.0047574 Editor:NatashaM.Maurits,UniversityMedicalCenterGroningenUMCG,TheNetherlands ReceivedJuly11,2012;AcceptedSep