Mortality and Hospital Stay Associated with Resistant Staphylococcus aureus and Escherichia coli Bacteremia Estimating the Burden of Antibiotic Resistance in Europe 英文参考文献.docVIP

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Mortality and Hospital Stay Associated with Resistant Staphylococcus aureus and Escherichia coli Bacteremia Estimating the Burden of Antibiotic Resistance in Europe 英文参考文献.doc

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Mortality and Hospital Stay Associated with Resistant Staphylococcus aureus and Escherichia coli Bacteremia Estimating the Burden of Antibiotic Resistance in Europe 英文参考文献

MortalityandHospitalStayAssociatedwithResistant StaphylococcusaureusandEscherichiacoliBacteremia: EstimatingtheBurdenofAntibioticResistanceinEurope MarliekeE.A.deKraker1,2*,PeterG.Davey3,HajoGrundmann1,2,onbehalfoftheBURDENstudygroup 1Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, 2Department of Medical Microbiology,AcademicMedicalCentreGroningen,Groningen,TheNetherlands,3Quality,SafetyandInformaticsResearchGroup,Dundee,UnitedKingdom Abstract Background:Therelativeimportanceofhumandiseasesisconventionallyassessedbycause-specificmortality,morbidity, andeconomicimpact.Currentestimatesforinfectionscausedbyantibiotic-resistantbacteriaarenotsufficientlysupported byquantitativeempiricaldata.Thisstudydeterminedtheexcessnumberofdeaths,bed-days,andhospitalcostsassociated with blood stream infections (BSIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) and third-generation cephalosporin-resistantEscherichiacoli(G3CREC)in31countriesthatparticipatedintheEuropeanAntimicrobialResistance SurveillanceSystem(EARSS). MethodsandFindings:ThenumberofBSIscausedbyMRSAandG3CRECwasextrapolatedfromEARSSprevalencedata and national health care statistics. Prospective cohort studies, carried out in hospitals participating in EARSS in 2007, providedtheparametersforestimatingtheexcess30-dmortalityandhospitalstayassociatedwithBSIscausedbyeither MRSAorG3CREC.Hospitalexpenditurewasderivedfromapubliclyavailablecostmodel.TrendsestablishedbyEARSSwere usedtodeterminethetrajectoriesforMRSAandG3CRECprevalenceuntil2015.In2007,27,711episodesofMRSABSIswere associated with 5,503 excess deaths and 255,683 excess hospital days in the participating countries, whereas 15,183 episodes of G3CREC BSIs were associated with 2,712 excess deaths and 120,065 extra hospital days. The total costs attributable to excess hospital stays for MRSA and G3CREC BSIs were 44.0 and 18.1 million Euros (63.1 and 29.7 million internati