Multiple Crimean-Congo Hemorrhagic Fever Virus Strains Are Associated with Disease Outbreaks in Sudan, 2008–2009 英文参考文献.docVIP

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Multiple Crimean-Congo Hemorrhagic Fever Virus Strains Are Associated with Disease Outbreaks in Sudan, 2008–2009 英文参考文献.doc

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Multiple Crimean-Congo Hemorrhagic Fever Virus Strains Are Associated with Disease Outbreaks in Sudan, 2008–2009 英文参考文献

MultipleCrimean-CongoHemorrhagicFeverVirus StrainsAreAssociatedwithDiseaseOutbreaksinSudan, 2008–2009 ImadeldinE.Aradaib1,BobbieR.Erickson2,MubarakS.Karsany3,MarinaL.Khristova4,RehabM. Elageb3,MohamedE.H.Mohamed1,StuartT.Nichol2* 1MolecularBiologyLaboratory,DepartmentofClinicalMedicine,FacultyofVeterinaryMedicine,UniversityofKhartoum,KhartoumNorth,Sudan, 2MolecularBiology Laboratory,ViralSpecialPathogensBranch,DivisionofHighConsequencePathogensandPathology,UnitedStatesCentersforDiseaseControlandPrevention,Atlanta, Georgia,UnitedStatesofAmerica,3DivisionofVirology,NationalMedicalHealthLaboratory,FederalMinistryofHealth,Khartoum,RepublicofSudan,4Biotechnology CoreFacilityBranch,DivisionofScientificResources,UnitedStatesCentersforDiseaseControlandPrevention,Atlanta,Georgia,UnitedStatesofAmerica Abstract Background: Crimean-Congo hemorrhagic fever (CCHF) activity has recently been detected in the Kordufan region of Sudan.Since2008,severalsporadiccasesandnosocomialoutbreaksassociatedwithhighcase-fatalityhavebeenreported invillagesandruralhospitalsintheregion. Principal Findings:Inthepresentstudy, wedescribe acluster ofcasesoccurring inJune2009 inDunkop village,Abyei District, South Kordufan, Sudan. Seven CCHF cases were involved in the outbreak; however, clinical specimens could be collected from only two patients, both of whom were confirmed as acute CCHF cases using CCHF-specific reverse transcriptase polymerase chain reaction(RT-PCR). Phylogeneticanalysis of thecomplete S,M, andL segmentsequences places the Abyei strain of CCHF virus in Group III, a virus group containing strains from various countries across Africa, includingSudan, SouthAfrica, Mauritania,andNigeria. TheAbyei straindetectedin 2009is geneticallydistinct fromthe recentlydescribed2008SudaneseCCHFvirusstrains(Al-fulah3and4),andtheAbyeistrainSandLsegmentscloselymatch thoseofCCHFvirusstrainArD39554fromMauritania. Conclusions:ThepresentinvestigationillustratesthatmultipleCCHFviruslineagesar