Myocardial Chemokine Expression and Intensity of Myocarditis in Chagas Cardiomyopathy Are Controlled by Polymorphisms in CXCL9 and CXCL10 英文参考文献.docVIP

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Myocardial Chemokine Expression and Intensity of Myocarditis in Chagas Cardiomyopathy Are Controlled by Polymorphisms in CXCL9 and CXCL10 英文参考文献.doc

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Myocardial Chemokine Expression and Intensity of Myocarditis in Chagas Cardiomyopathy Are Controlled by Polymorphisms in CXCL9 and CXCL10 英文参考文献

MyocardialChemokineExpressionandIntensityof MyocarditisinChagasCardiomyopathyAreControlled byPolymorphismsinCXCL9andCXCL10 LucianaGabrielNogueira1,2,3,RonaldoHonoratoBarrosSantos4,BarbaraMariaIanni5, AlfredoIna′cioFiorelli4,ElianeContiMairena1,2,3,LuizAlbertoBenvenuti6,AmandaFrade1,2,3, EduardoDonadi7,Fabr?′cioDias7,BrunoSaba8,Hui-TzuLinWang8,AbilioFragata8,MarceloSampaio8, MarioHiroyukiHirata8,PaulaBuck5,CharlesMady5,EdimarAlcidesBocchi9,NoedirAntonioStolf4, JorgeKalil1,2,3,EdecioCunha-Neto1,2,3 * 1LaboratoryofImmunology,HeartInstitute(InCor),SchoolofMedicine,UniversityofSa?oPaulo,Sa?oPaulo,Brazil,2DivisionofClinicalImmunologyandAllergy,Schoolof Medicine,UniversityofSa?o Paulo,Sa?o Paulo,Brazil,3InstituteforInvestigationinImmunology(iii),INCT,Sa?o Paulo,Brazil,4DivisonofSurgery,HeartInstitute(InCor), SchoolofMedicine,UniversityofSa?o Paulo,Sa?o Paulo,Brazil,5MyocardiopathiesUnit,HeartInstitute(InCor),SchoolofMedicine,UniversityofSa?o Paulo,Sa?o Paulo, Brazil, 6Divison of Pathology, Heart Institute (InCor), School of Medicine, University of Sa?o Paulo, Sa?o Paulo, Brazil, 7School of Medicine of Ribeira?o Preto (FMRP), UniversityofSa?o Paulo,Sa?o Paulo,Brazil,8DantePazzaneseInstituteofCardiologyandHeartFailureUnit,Sa?o Paulo,Brazil,9TransplantationandHeartFailureUnit, HeartInstitute(InCor),SchoolofMedicine,UniversityofSa?o Paulo,Sa?o Paulo,Brazil Abstract Background:ChronicChagascardiomyopathy(CCC),alife-threateninginflammatorydilatedcardiomyopathy,affects30% oftheapproximately8millionpatientsinfectedbyTrypanosomacruzi.EventhoughtheTh1Tcell-richmyocarditisplaysa pivotal role in CCC pathogenesis, little is known about the factors controlling inflammatory cell migration to CCC myocardium. MethodsandResults:UsingconfocalimmunofluorescenceandquantitativePCR,westudiedcellsurfacestainingandgene expressionoftheCXCR3,CCR4,CCR5,CCR7,CCR8receptorsandtheirchemokineligandsinmyocardialsamplesfromend- stage CCC patients. CCR5+, CXCR3+, CCR4+, CCL5+ and