Neurodegenerative Properties of Chronic Pain Cognitive Decline in Patients with Chronic Pancreatitis 英文参考文献.docVIP

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Neurodegenerative Properties of Chronic Pain Cognitive Decline in Patients with Chronic Pancreatitis 英文参考文献.doc

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Neurodegenerative Properties of Chronic Pain Cognitive Decline in Patients with Chronic Pancreatitis 英文参考文献

NeurodegenerativePropertiesofChronicPain:Cognitive DeclineinPatientswithChronicPancreatitis MarijtjeL.A.Jongsma1,2.,SimoneA.E.Postma1.,PierreSouren3,MartijnArns4,EvianGordon5 ,Kris Vissers6,OliverWilder-Smith6,ClementinaM.vanRijn1*,HarryvanGoor7 1Donders Centre for Cognition, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands, 2Department of Learning and Development, Behavioral Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands, 3Research Technical Support Group (RTOG), DepartmentofSocialPsychology,RadboudUniversityNijmegen,Nijmegen,TheNetherlands,4ResearchInstitute Brainclinics,Nijmegen,TheNetherlands,5TheBrain Resource International Database and the Brain Resource Company, Ultimo, Australia, 6Pain and Nociception Neuroscience Research Group, Department of Anaesthesiology,PainandPalliativeMedicine,RadboudUniversityNijmegenMedicalCentre,Nijmegen,TheNetherlands,7PainandNociceptionNeuroscienceResearch Group,DepartmentofSurgery,RadboudUniversityNijmegenMedicalCentre,Nijmegen,TheNetherlands Abstract Chronicpainhasbeenassociatedwithimpairedcognitivefunction.Weexaminedcognitiveperformanceinpatientswith severechronicpancreatitispain.Weexploredthefollowingfactorsfortheircontributiontoobservedcognitivedeficits:pain duration,comorbidity(depression,sleepdisturbance),useofopioids,andpremorbidalcoholabuse.Thecognitiveprofiles of16patientswithseverepain duetochronicpancreatitis weredeterminedusinganextensiveneuropsychological test battery.Datafromthreecognitivedomains(psychomotorperformance,memory,executivefunctions)werecomparedto data from healthy controls matched for age, gender and education. Multivariate multilevel analysis of the data showed decreasedtestscoresinpatientswithchronicpancreatitispainindifferentcognitivedomains.Psychomotorperformance and executive functions showed the most prominent decline. Interestingly, pain duration appeared to be the strongest predictorforobservedc