Nicotianamine, a Novel Enhancer of Rice Iron Bioavailability to Humans 英文参考文献.docVIP

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Nicotianamine, a Novel Enhancer of Rice Iron Bioavailability to Humans 英文参考文献.doc

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Nicotianamine, a Novel Enhancer of Rice Iron Bioavailability to Humans 英文参考文献

Nicotianamine,aNovelEnhancerofRiceIron BioavailabilitytoHumans LuqingZheng1,ZhiqiangCheng2,ChunxiangAi2,XinhangJiang1,XiaoshuBei1,2,YeZheng1,RaymondP. Glahn3,RossM.Welch3,DennisD.Miller2,XinGenLei2*,HuixiaShou1* 1StateKeyLaboratoryofPlantPhysiologyandBiochemistry,CollegeofLifeSciences,ZhejiangUniversity,Hangzhou,China,2DepartmentsofAnimalScienceandFood Science,CornellUniversity,Ithaca,NewYork,UnitedStatesofAmerica,3UnitedStateDepartmentofAgriculture-AgriculturalResearchService,RobertW.HolleyCenter forAgricultureandHealth,CornellUniversity,Ithaca,NewYork,UnitedStatesofAmerica Abstract Background:Polishedriceisastaplefoodforover50%oftheworld’spopulation,butcontainslittlebioavailableiron(Fe)to meethumanneeds.Thus,biofortifyingthericegrainwithnovelpromotersorenhancersofFeutilizationwouldbeoneof themosteffectivestrategiestopreventthehighprevalenceofFedeficiencyandirondeficiencyanemiainthedeveloping world. Methodology/PrincipalFindings:WetransformedanelitericelinecultivatedinSouthernChinawiththericenicotianamine synthasegene(OsNAS1)fusedtoariceglutelinpromoter.EndospermoverexpressionofOsNAS1resultedinasignificant increaseinnicotianamine(NA)concentrationsinbothunpolishedandpolishedgrain.BioavailabilityofFefromthehighNA grain, asmeasured by ferritin synthesisin an invitro Caco-2 cell model that simulatesthe human digestivesystem, was twiceasmuchasthatofthecontrolline.Whenaddedat1:1molarratiotoferrousFeinthecellsystem,NAwastwiceas effective when compared toascorbic acid (one ofthe mostpotent known enhancersof Febioavailability) in promoting moreferritinsynthesis. Conclusions:OurdatademonstratedthatNAisanovelandeffectivepromoterofironutilization.Biofortifyingpolishedrice withthiscompoundhasgreatpotentialincombatingglobalhumanirondeficiencyinpeopledependentonricefortheir sustenance. Citation:ZhengL,ChengZ,AiC,JiangX,BeiX,etal.(2010)Nicotianamine,aNovelEnhancerofRiceIronBioavailabilitytoHumans.PLoSONE5(4):e10190. doi:10.1371/journal.pone.0010190 Editor:EdwardNewbigin,Universi