No Effect of a Single Session of Transcranial Direct Current Stimulation on Experimentally Induced Pain in Patients with Chronic Low Back Pain – An Exploratory Study 英文参考文献.docVIP

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No Effect of a Single Session of Transcranial Direct Current Stimulation on Experimentally Induced Pain in Patients with Chronic Low Back Pain – An Exploratory Study 英文参考文献.doc

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No Effect of a Single Session of Transcranial Direct Current Stimulation on Experimentally Induced Pain in Patients with Chronic Low Back Pain – An Exploratory Study 英文参考文献

NoEffectofaSingleSessionofTranscranialDirect CurrentStimulationonExperimentallyInducedPainin PatientswithChronicLowBackPain–AnExploratory Study KerstinLuedtke*,ArneMay,TimP.Ju¨rgens DepartmentofSystemsNeuroscience,UniversityMedicalCentreHamburg-Eppendorf,Hamburg,Germany Abstract Transcranialdirectcurrentstimulation(tDCS)hasbeenshowntomodulatecorticalexcitability.Asmallnumberofstudies suggestedthattDCSmodulatestheresponsetoexperimentalpainparadigms.Notrialshavebeenconductedtoevaluate theresponseofpatientsalreadysufferingfrompain,toanadditionalexperimentalpainbeforeandaftertDCS.Thepresent studyinvestigatedtheeffectofasinglesessionofanodal,cathodalandshamstimulation(15mins/1mA)overtheprimary motorcortexontheperceivedintensityofrepeatednoxiousthermalandelectricalstimuliandonelementsofquantitative sensorytesting(thermalpainandperceptionthresholds)appliedtotherighthandin15patientswithchroniclowback pain.Thestudywasconductedinadouble-blindsham-controlledandcross-overdesign.Nosignificantalterationsofpain ratings were found. Modalities of quantitative sensory testing remained equally unchanged. It is therefore hypothesized thatasingle15minssessionoftDCSat1mAmaynotbesufficienttoaltertheperceptionofexperimentalpainandin patients with chronic pain. Further studies applying repetitive tDCS to patients with chronic pain are required to fully answerthequestionwhetherexperimentalpainperceptionmaybeinfluencedbytDCSoverthemotorcortex. Citation:LuedtkeK,MayA,Ju¨rgensTP(2012)NoEffectofaSingleSessionofTranscranialDirectCurrentStimulationonExperimentallyInducedPaininPatients withChronicLowBackPain–AnExploratoryStudy.PLoSONE7(11):e48857.doi:10.1371/journal.pone.0048857 Editor:SamEldabe,TheJamesCookUniversityHospital,UnitedKingdom ReceivedApril19,2012;AcceptedOctober1,2012;PublishedNovember26,2012 Copyright: ? 2012 Luedtke et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproducti