Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography 英文参考文献.docVIP
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Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography 英文参考文献
Noninvasive,InVivoAssessmentofMouseRetinal
StructureUsingOpticalCoherenceTomography
M.DominikFischer1.,GesineHuber1,2.,SusanneC.Beck1,NaoyukiTanimoto1,RegineMuehlfriedel1,
EddaFahl1,ChristianGrimm3,AndreasWenzel3¤a,CharlotteE.Reme′3,SergeA.vandePavert4¤b ,Jan
Wijnholds4,MarekPacal5,RodBremner5,MathiasW.Seeliger1*
1Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany, 2Institute of
Animal Welfare, Ethology and Animal Hygiene, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany, 3Laboratory of Retinal Cell Biology,
University of Zurich, Zurich, Switzerland, 4Neuromedical Genetics, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands, 5Toronto Western Research
Institute, University Health Network, Departments of Ophthalmology and Visual Science, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto,
Ontario,Canada
Abstract
Background:Opticalcoherencetomography(OCT)isanovelmethodofretinalinvivoimaging.Inthisstudy,weassessed
thepotentialofOCTtoyieldhistology-analoguesectionsinmousemodelsofretinaldegeneration.
Methodology/PrincipalFindings:Weachievedtoadaptacommercial3rdgenerationOCTsystemtoobtainandquantifyhigh-
resolution morphological sections of the mouse retina which so far required in vitro histology. OCT and histology were
comparedinmodelswithdevelopmentaldefects,lightdamage,andinheritedretinaldegenerations.Inconditionalknockout
micedeficientin retinalretinoblastomaprotein Rb, the gradient ofCreexpression from centertoperiphery, leading toa
gradualreductionofretinalthickness,wasclearlyvisibleandwelltopographicallyquantifiable.InNrlknockoutmice,thelayer
involvement in the formation of rosette-like structures was similarly clear as in histology. OCT examination of focal light
damage, well demarcated by the autofluorescence pattern, revealed a practically complete loss of photoreceptors with
preservationofinnerretina
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