Novel Secretion Apparatus Maintains Spore Integrity and Developmental Gene Expression in Bacillus subtilis 英文参考文献.docVIP
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Novel Secretion Apparatus Maintains Spore Integrity and Developmental Gene Expression in Bacillus subtilis 英文参考文献
NovelSecretionApparatusMaintainsSporeIntegrityand
DevelopmentalGeneExpressioninBacillussubtilis
ThierryDoan1.,CecileMorlot1.,JeffreyMeisner2,MonicaSerrano3,AdrianoO.Henriques3,CharlesP.
Moran,Jr.2,DavidZ.Rudner1*
1Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, 2Department of Microbiology and
Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America, 3Microbial Development Group, Instituto de Tecnologia Qu?′mica e
Biolo′gica,UniversidadeNovadeLisboa,Oeiras,Portugal
Abstract
SporulationinBacillussubtilisinvolvestwocellsthatfollowseparatebutcoordinatelyregulateddevelopmentalprograms.
Late in sporulation, the developing spore (the forespore) resides within a mother cell. The regulation of the forespore
transcription factor sG that acts at this stage has remained enigmatic. sG activity requires eight mother-cell proteins
encoded in the spoIIIA operon and the forespore protein SpoIIQ. Several of the SpoIIIA proteins share similarity with
components of specialized secretion systems. One of them resembles a secretion ATPase and we demonstrate that the
ATPase motifs are required for sG activity. We further show that the SpoIIIA proteins and SpoIIQ reside in a multimeric
complexthatspansthetwomembranessurroundingtheforespore.Finally,wehavediscoveredthattheseproteinsareall
required to maintain forespore integrity. In their absence, the forespore develops large invaginations and collapses.
Importantly,maintenanceofforesporeintegritydoesnotrequiresG.TheseresultssupportamodelinwhichtheSpoIIIA-
SpoIIQproteinsformanovelsecretionapparatusthatallowsthemothercelltonurturetheforespore,therebymaintaining
foresporephysiologyandsGactivityduringsporematuration.
Citation: DoanT,MorlotC, MeisnerJ,SerranoM,Henriques AO,etal.(2009)NovelSecretion Apparatus MaintainsSporeIntegrityandDevelopmentalGene
ExpressioninBacillussubtilis.PLoSGenet5(7):e1000566.doi:10.1371/journal.pgen.100
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