Novel and Conserved Protein Macoilin Is Required for Diverse Neuronal Functions in Caenorhabditis elegans 英文参考文献.docVIP
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Novel and Conserved Protein Macoilin Is Required for Diverse Neuronal Functions in Caenorhabditis elegans 英文参考文献
NovelandConservedProteinMacoilinIsRequiredfor
DiverseNeuronalFunctionsinCaenorhabditiselegans
AkikoMiyara1,AkaneOhta1¤a,YoshifumiOkochi1¤b,YukiTsukada1,AtsushiKuhara1,IkueMori1,2*
1LaboratoryofMolecularNeurobiology,DepartmentofMolecularBiology,GraduateSchoolofScience,NagoyaUniversity,Nagoya,Japan,2CREST,JapanScienceand
TechnologyAgency,Saitama,Japan
Abstract
Neuralsignalsareprocessedinnervoussystemsofanimalsrespondingtovariableenvironmentalstimuli.Thisstudyshows
that a novel and highly conserved protein, macoilin (MACO-1), plays an essential role in diverse neural functions in
Caenorhabditis elegans. maco-1 mutants showed abnormal behaviors, including defective locomotion, thermotaxis, and
chemotaxis. Expression of human macoilin in the C. elegans nervous system weakly rescued the abnormal thermotactic
phenotypeofthemaco-1mutants,suggestingthatmacoilinisfunctionallyconservedacrossspecies.Abnormalthermotaxis
may have been caused by impaired locomotion of maco-1 mutants. However, calcium imaging of AFD thermosensory
neuronsandAIYpostsynapticinterneuronsofmaco-1mutantssuggestthatmacoilinisrequiredforappropriateresponses
ofAFDandAIYneuronstothermalstimuli.StudiesonlocalizationofMACO-1showedthatC.elegansandhumanmacoilins
arelocalizedmainlytotheroughendoplasmicreticulum.Ourresultssuggestthatmacoilinisrequiredforvariousneural
events,suchastheregulationofneuronalactivity.
Citation:MiyaraA,OhtaA,OkochiY,TsukadaY,KuharaA,etal.(2011)NovelandConservedProteinMacoilinIsRequiredforDiverseNeuronalFunctionsin
Caenorhabditiselegans.PLoSGenet7(5):e1001384.doi:10.1371/journal.pgen.1001384
Editor:AndrewD.Chisholm,UniversityofCaliforniaSanDiego,UnitedStatesofAmerica
ReceivedJune1,2010;AcceptedApril8,2011;PublishedMay12,2011
Copyright: ? 2011 Miyara et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:IMisa
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