NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice 英文参考文献.docVIP

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NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice 英文参考文献.doc

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NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice 英文参考文献

NPYNeuron-SpecificY2ReceptorsRegulateAdipose TissueandTrabecularBonebutNotCorticalBone HomeostasisinMice Yan-ChuanShi1,ShuLin1,IrisP.L.Wong1,PaulA.Baldock1,3,AygulAljanova1,RonaldoF.Enriquez1, LesleyCastillo1,NatalieF.Mitchell1,Ji-MingYe2,LeiZhang1,LaurenceMacia1,ErnieYulyaningsih1, AmyD.Nguyen1,SabrinaJ.Riepler1,HerbertHerzog1,3.,AmandaSainsbury 1,4 . * 1NeuroscienceResearchProgram,GarvanInstituteofMedicalResearch,Sydney,NewSouthWales,Australia,2DiabetesandObesityResearchProgram,GarvanInstitute ofMedicalResearch,Sydney,NewSouthWales,Australia,3FacultyofMedicine,UniversityofNewSouthWales,Sydney,NewSouthWales,Australia,4SchoolofMedical Sciences,UniversityofNewSouthWales,Sydney,NewSouthWales,Australia Abstract Background: Y2 receptor signalling is known to be important in neuropeptide Y (NPY)-mediated effects on energy homeostasisandbonephysiology.Y2receptorsarelocatedpost-synapticallyaswellasactingasautoreceptorsonNPY- expressing neurons, and the different roles of these two populations of Y2 receptors in the regulation of energy homeostasisandbodycompositionareunclear. lox/lox Methodology/Principal Findings: We thus generated two conditional knockout mouse models, Y2 and NPYCre/ +;Y2lox/lox,inwhichY2receptorscanbeselectivelyablatedeitherinthehypothalamusorspecificallyinhypothalamicNPY- producingneuronsofadultmice.SpecificdeletionofhypothalamicY2receptorsincreasesfoodintakeandbodyweight comparedtocontrols.Importantly,specificablationofhypothalamicY2receptorsonNPY-containingneuronsresultsina significantlygreateradiposityinfemalebutnotmalemice,accompaniedbyincreasedhepatictriglyceridelevels,decreased expression of liver cartinine palmitoyltransferase (CPT1) and increased expression of muscle phosphorylated acetyl-CoA carboxylase(ACC).Whilefoodintake,bodyweight,femurlength,bonemineralcontent,densityandcorticalbonevolume and thickness are not significantly altered, trabecular bone volume and number were significantly increased by hypothalamic Y2 deletion on NPY-expre