Nuclear beta-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer 英文参考文献.docVIP
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Nuclear beta-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer 英文参考文献
Chengetal.DiagnosticPathology2011,6:109
/content/6/1/109
RESEARCH
OpenAccess
Nuclearbeta-cateninoverexpressioninmetastatic
sentinellymphnodeisassociatedwith
synchronouslivermetastasisincolorectalcancer
HongxiaCheng1*,HuiLiang2,YejunQin1andYingLiu1
Abstract
Background:Beta-catenin,acomponentoftheWingless/Wntsignalingpathway,canactivatetargetgeneslinking
withtheadenomatouspolyposiscoli(APC)geneincolorectalcancer.Thepurposeofthisstudyistoinvestigate
whethernuclearbeta-cateninoverexpressioninmetastaticsentinellymphnode(s)[SLN(s)]isassociatedwith
synchronouslivermetastasis.
Methods:Clinicopathologicaldatafrom355patients(93caseswithlivermetastasisand262caseswithoutliver
metastasis)werereviewed.Beta-cateninexpressioninmetastaticSLN(s)andlivermetastaticlesionswasexamined
byimmunohistochemistry.Theassociationofnuclearbeta-cateninexpressioninmetastaticSLN(s)andliver
metastaticlesionswasevaluated,andtherelationshipbetweennuclearbeta-cateninexpressionand
clinicopathologicalcharacteristicswasanalyzed.Finally,univariateandlogisticmultivariateregressionanalyseswere
adoptedtodiscriminatetheriskfactorsoflivermetastasis.
Results:Nuclearbeta-cateninoverexpressioninmetastaticSLN(s)wasobservedin70patientswithlivermetastasis
and31patientswithoutlivermetastasis(75.3%vs.11.8%;P0.001).Nuclearbeta-cateninexpressionwasnotedin
allthemetastaticlesions.Spearmanrankcorrelationanalysisdemonstratedthatnuclearbeta-cateninexpressionin
metastaticSLN(s)hadapositivecorrelationwiththatinmetastaticlesions(r=0.425,P0.001).Univariateand
multivariateanalysesindicatedthatnuclearbeta-cateninoverexpressioninmetastaticSLN(s)correlatedwithliver
metastasis.
Conclusions:Nuclearbeta-cateninoverexpressioninmetastaticSLN(s)isstronglyassociatedwithlivermetastasis
andmaycontributetopredictlivermetastasis.
Keywords:Beta-catenin,Colorectalcancer,Livermetastasis,Sentinellymphnode
Background
detectionoflivermetastasisinCRCisespeciallyimpor-
Colorectal cancer (CRC) is one of the most common tant to improve patient surviva
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