Outcomes of Patients with Benign Liver Diseases Undergoing Living Donor versus Deceased Donor Liver Transplantation 英文参考文献.docVIP

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Outcomes of Patients with Benign Liver Diseases Undergoing Living Donor versus Deceased Donor Liver Transplantation 英文参考文献.doc

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Outcomes of Patients with Benign Liver Diseases Undergoing Living Donor versus Deceased Donor Liver Transplantation 英文参考文献

OutcomesofPatientswithBenignLiverDiseases UndergoingLivingDonorversusDeceasedDonorLiver Transplantation ChuanLi,KaiMi,TianfuWen*,LunanYan,BoLi,JiayingYang,MingqingXu,WentaoWang,Yong gangWei DivisionofLiverTransplantation,WestChinaHospital,SichuanUniversity,Chengdu,SichuanProvince,China Abstract Background/Aims: The number of people undergoing living donor liver transplantation (LDLT) has increased rapidly in many transplant centres. Patients considering LDLT need to know whether LDLT is riskier than deceased donor liver transplantation(DDLT).TheaimofthisstudywastocomparetheoutcomesofpatientsundergoingLDLTversusDDLT. Methods: A total of 349 patients with benign liver diseases were recruited from 2005 to 2011 for this study. LDLT was performedin128patients,andDDLTwasperformedin221patients.Pre-andintra-operativevariablesforthetwogroups werecompared.Statisticallyanalysedpost-operativeoutcomesincludethepostoperativeincidenceofcomplication,biliary and vascular complication, hepatitis B virus (HBV) recurrence, long-term survival rate and outcomes of emergency transplantation. Results: The waiting times were 22.10615.31 days for the patients undergoing LDLT versus 35.81629.18 days for the patientsundergoingDDLT.Thecoldischemiatime(CIT)was119.34619.75minutesfortheLDLTgroupand3466154.18for DDLTgroup.LDLTgrouphadhigherintraoperativebloodloss,butredbloodcell(RBC)transfusionwasnotdifferent.Similar $ Clavien III complications, vascular complications, hepatitis B virus (HBV) recurrence and long-term survival rates were noted.LDLTpatientssufferedahigherincidenceofbiliarycomplicationsintheearlypostoperativedays.However,during thelong-termfollow-upperiod,biliarycomplicationratesweresimilarbetweenthetwogroups.Thelong-termsurvivalrate of patients undergoing emergency transplantation was lower than of patients undergoing elective transplantation. However,nosignificantdifferencewasobservedbetweenemergencyLDLTandemergencyDDLT. Conclusions:PatientsundergoingLDLTachievedsimilaroutcomestop