Outlining eicosanoid biosynthesis in the crustacean Daphnia 英文参考文献.docVIP

Frontiers in Zoology BioMedCentral Research Open Access Outlining eicosanoid biosynthesis in the crustacean Daphnia Lars-Henrik Heckmann*1,2, Richard M Sibly1, Martijn JTN Timmermans3 and Amanda Callaghan1 Address: 1University of Reading, School of Biological Sciences, Environmental Biology, PO Box 68, Reading, RG6 6BX, UK, 2University of Aarhus, National Environmental Research Institute, Department of Terrestrial Ecology, Vejls?vej 25, PO Box 314, DK-8600, Silkeborg, Denmark and 3VU University Amsterdam, Institute of Ecological Science, Department of Animal Ecology, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands Email: Lars-Henrik Heckmann* - lhh@dmu.dk; Richard M Sibly - r.m.sibly@reading.ac.uk; Martijn JTN Timmermans - martijn.timmermans@falw.vu.nl; Amanda Callaghan - a.callaghan@reading.ac.uk * Corresponding author Published: 14 July 2008 Received: 28 March 2008 Accepted: 14 July 2008 Frontiers in Zoology 2008, 5:11 doi:10.1186/1742-9994-5-11 This article is available from: /content/5/1/11 ? 2008 Heckmann et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Eicosanoids are biologically active, oxygenated metabolites of three C20 polyunsaturated fatty acids. They act as signalling molecules within the autocrine or paracrine system in both vertebrates and invertebrates mainly functioning as important mediators in reproduction, the immune system and ion transport. The biosynthesis of eicosanoids has been intensively studied in mammals and it is known that they are synthesised from the fatty acid, arachidonic acid, through either the cyclooxygenase (COX) pathway; the lipoxygenase (LOX) pathway; or the cytochrome P450 epoxygenase